Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

For many decades, the inability of lesioned central neurons to regrow was accepted almost
as a" law of nature", and on the clinical level, spinal cord and brain lesions were seen as …

Injury reproducibility is an important characteristic of experimental models of spinal cord
injuries (SCI) because it limits the variability in locomotor and anatomical outcome …

In the central nervous system (CNS), the transcription factor nuclear factor (NF)-κB is a key
regulator of inflammation and secondary injury processes. After trauma or disease, the …

We examined the ability of a novel spinal cord injury (SCI) device to produce graded
morphological and behavioral changes in the adult rat following an injury at thoracic level 10 …

Post-traumatic cystic cavitation, in which the size and severity of a CNS injury progress from
a small area of direct trauma to a greatly enlarged secondary injury surrounded by glial scar …

Traumatic spinal cord injury results in the disruption of neural and vascular structures
(primary injury) and is characterized by an evolution of secondary pathogenic events that …

Spinal cord injury (SCI) is a major cause of disability, and at present, there is no universally
accepted treatment. The functional decline following SCI is contributed to both direct …

Inflammation in general and proteinases generated as a result are likely mediators of early
secondary pathogenesis after spinal cord injury. We report that matrix metalloproteinase-9 …

Current treatments for acute spinal cord injury are based on animal models of human spinal
cord injury (SCI). These models have shown that the initial traumatic injury to cord tissue is …