Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms
A Alizadeh, SM Dyck, S Karimi-Abdolrezaee - Frontiers in neurology, 2019 - frontiersin.org
Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …
socioeconomic implications for patients and their care-givers. Recent advances in medical …
Degeneration and regeneration of axons in the lesioned spinal cord
ME Schwab, D Bartholdi - Physiological reviews, 1996 - journals.physiology.org
For many decades, the inability of lesioned central neurons to regrow was accepted almost
as a" law of nature", and on the clinical level, spinal cord and brain lesions were seen as …
as a" law of nature", and on the clinical level, spinal cord and brain lesions were seen as …
Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection
Injury reproducibility is an important characteristic of experimental models of spinal cord
injuries (SCI) because it limits the variability in locomotor and anatomical outcome …
injuries (SCI) because it limits the variability in locomotor and anatomical outcome …
[HTML][HTML] Inhibition of astroglial nuclear factor κB reduces inflammation and improves functional recovery after spinal cord injury
In the central nervous system (CNS), the transcription factor nuclear factor (NF)-κB is a key
regulator of inflammation and secondary injury processes. After trauma or disease, the …
regulator of inflammation and secondary injury processes. After trauma or disease, the …
Experimental modeling of spinal cord injury: characterization of a force-defined injury device
SW Scheff, AG Rabchevsky, I Fugaccia… - Journal of …, 2003 - liebertpub.com
We examined the ability of a novel spinal cord injury (SCI) device to produce graded
morphological and behavioral changes in the adult rat following an injury at thoracic level 10 …
morphological and behavioral changes in the adult rat following an injury at thoracic level 10 …
Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitroanalysis of inflammation-induced secondary injury after CNS …
MT Fitch, C Doller, CK Combs… - Journal of …, 1999 - Soc Neuroscience
Post-traumatic cystic cavitation, in which the size and severity of a CNS injury progress from
a small area of direct trauma to a greatly enlarged secondary injury surrounded by glial scar …
a small area of direct trauma to a greatly enlarged secondary injury surrounded by glial scar …
Vascular events after spinal cord injury: contribution to secondary pathogenesis
AEM Mautes, MR Weinzierl, F Donovan… - Physical …, 2000 - academic.oup.com
Traumatic spinal cord injury results in the disruption of neural and vascular structures
(primary injury) and is characterized by an evolution of secondary pathogenic events that …
(primary injury) and is characterized by an evolution of secondary pathogenic events that …
Degenerative and regenerative mechanisms governing spinal cord injury
C Profyris, SS Cheema, DW Zang, MF Azari… - Neurobiology of …, 2004 - Elsevier
Spinal cord injury (SCI) is a major cause of disability, and at present, there is no universally
accepted treatment. The functional decline following SCI is contributed to both direct …
accepted treatment. The functional decline following SCI is contributed to both direct …
Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events
LJ Noble, F Donovan, T Igarashi… - Journal of …, 2002 - Soc Neuroscience
Inflammation in general and proteinases generated as a result are likely mediators of early
secondary pathogenesis after spinal cord injury. We report that matrix metalloproteinase-9 …
secondary pathogenesis after spinal cord injury. We report that matrix metalloproteinase-9 …
Cell death in models of spinal cord injury
MS Beattie, GE Hermann, RC Rogers… - Progress in brain …, 2002 - Elsevier
Current treatments for acute spinal cord injury are based on animal models of human spinal
cord injury (SCI). These models have shown that the initial traumatic injury to cord tissue is …
cord injury (SCI). These models have shown that the initial traumatic injury to cord tissue is …