[PDF][PDF] Vascular tissue engineering: progress, challenges, and clinical promise

HHG Song, RT Rumma, CK Ozaki, ER Edelman… - Cell stem cell, 2018 - cell.com
Although the clinical demand for bioengineered blood vessels continues to rise, current
options for vascular conduits remain limited. The synergistic combination of emerging …

[HTML][HTML] N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer

KM Mrozik, OW Blaschuk, CM Cheong… - BMC cancer, 2018 - Springer
In many types of solid tumours, the aberrant expression of the cell adhesion molecule N-
cadherin is a hallmark of epithelial-to-mesenchymal transition, resulting in the acquisition of …

[HTML][HTML] Integration of substrate-and flow-derived stresses in endothelial cell mechanobiology

CA Dessalles, C Leclech, A Castagnino… - Communications …, 2021 - nature.com
Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …

Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids

VS Shirure, Y Bi, MB Curtis, A Lezia… - Lab on a Chip, 2018 - pubs.rsc.org
Most cancer treatment strategies target cell proliferation, angiogenesis, migration, and
intravasation of tumor cells in an attempt to limit tumor growth and metastasis. An in vitro …

From arteries to capillaries: approaches to engineering human vasculature

S Fleischer, DN Tavakol… - Advanced functional …, 2020 - Wiley Online Library
From microscaled capillaries to millimeter‐sized vessels, human vasculature spans multiple
scales and cell types. The convergence of bioengineering, materials science, and stem cell …

Microfabricated blood vessels for modeling the vascular transport barrier

WJ Polacheck, ML Kutys, JB Tefft, CS Chen - Nature protocols, 2019 - nature.com
The vascular endothelium forms the inner lining of blood vessels and actively regulates
vascular permeability in response to chemical and physical stimuli. Understanding the …

Microfluidics‐based biomaterials and biodevices

R Dong, Y Liu, L Mou, J Deng, X Jiang - Advanced Materials, 2019 - Wiley Online Library
The rapid development of microfluidics technology has promoted new innovations in
materials science, particularly by interacting with biological systems, based on precise …

[HTML][HTML] Engineered models to parse apart the metastatic cascade

LA Hapach, JA Mosier, W Wang… - NPJ precision …, 2019 - nature.com
While considerable progress has been made in studying genetic and cellular aspects of
metastasis with in vitro cell culture and in vivo animal models, the driving mechanisms of …

3D liver tissue model with branched vascular networks by multimaterial bioprinting

X Liu, X Wang, L Zhang, L Sun, H Wang… - Advanced …, 2021 - Wiley Online Library
Complicated vessels pervade almost all body tissues and influence the pathophysiology of
the human body significantly. However, current fabrication strategies have limited success at …

[HTML][HTML] Epstein− Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas

E Anastasiadou, D Stroopinsky, S Alimperti, AL Jiao… - Leukemia, 2019 - nature.com
Cancer cells subvert host immune surveillance by altering immune checkpoint (IC) proteins.
Some Epstein− Barr virus (EBV)-associated tumors have higher Programmed Cell Death …