Nanomedicines: current status and future perspectives in aspect of drug delivery and pharmacokinetics

YH Choi, HK Han - Journal of pharmaceutical investigation, 2018 - Springer
Nanomedicines have evolved into various forms including dendrimers, nanocrystals,
emulsions, liposomes, solid lipid nanoparticles, micelles, and polymeric nanoparticles since …

Nanodrugs: pharmacokinetics and safety

S Onoue, S Yamada, HK Chan - International journal of …, 2014 - Taylor & Francis
To date, various nanodrug systems have been developed for different routes of
administration, which include dendrimers, nanocrystals, emulsions, liposomes, solid lipid …

Exploring the application of micellar drug delivery systems in cancer nanomedicine

Q Wang, K Atluri, AK Tiwari, RJ Babu - Pharmaceuticals, 2023 - mdpi.com
Various formulations of polymeric micelles, tiny spherical structures made of polymeric
materials, are currently being investigated in preclinical and clinical settings for their …

Oral bioavailability enhancement through supersaturation: an update and meta-analysis

SYK Fong, A Bauer-Brandl, M Brandl - Expert opinion on drug …, 2017 - Taylor & Francis
Introduction: With the increasing number of poorly water-soluble compounds in drug
discovery pipelines, supersaturating drug delivery systems (SDDS) have attracted increased …

Production of hydrochlorothiazide nanoparticles with increased permeability using top-spray coating process

V Verma, P Patel, KM Ryan, S Hudson… - The Journal of …, 2023 - Elsevier
Hydrochlorothiazide is a diuretic drug and belongs to Biopharmaceutical Classification
System class IV, having poor water solubility and low permeability, thus proportionally …

Preparation and characterization of solid dispersion using a novel amphiphilic copolymer to enhance dissolution and oral bioavailability of sorafenib

DH Truong, TH Tran, T Ramasamy, JY Choi, HG Choi… - Powder Technology, 2015 - Elsevier
The objective of the current study was to enhance dissolution and oral bioavailability of the
poorly water-soluble drug, sorafenib (SFN), by solid dispersion (SD) technique using a novel …

Self-nanomicellizing solid dispersion: A promising platform for oral drug delivery

W Chen, A Yan, T Sun, X Wang, W Sun… - Colloids and Surfaces B …, 2024 - Elsevier
Amorphous solid dispersion (ASD) has been widely used to enhance the oral bioavailability
of water-insoluble drugs for oral delivery because of its advantages of enhancing solubility …

The efficiency and mechanism of N-octyl-O, N-carboxymethyl chitosan-based micelles to enhance the oral absorption of silybin

T Yin, Y Zhang, Y Liu, Q Chen, Y Fu, J Liang… - International Journal of …, 2018 - Elsevier
This study demonstrates the preparation of a silybin-loaded N-octyl-O, N-carboxymethyl
chitosan micelle (OCC-SLB) to enhance the oral absorption efficiency of silybin (SLB) and …

Self-micellizing solid dispersion of cyclosporine A with improved dissolution and oral bioavailability

S Onoue, H Suzuki, Y Kojo, S Matsunaga… - European Journal of …, 2014 - Elsevier
The present study aimed to develop a self-micellizing solid dispersion (SMSD) of
cyclosporine A (CsA) using an amphiphilic block copolymer, poly [MPC-co-BMA], to improve …

Water-soluble and amphiphilic phospholipid copolymers having 2-methacryloyloxyethyl phosphorylcholine units for the solubilization of bioactive compounds

K Ishihara, M Mu, T Konno - Journal of Biomaterials Science …, 2018 - Taylor & Francis
We summarize the development and evaluation of new type of phospholipid polymers as a
solubilizer for poorly water-soluble compounds. That is, a water-soluble and amphiphilic …