Obesity has become a major public health problem. Given the current increase in life
expectancy, the prevalence of obesity also raises steadily among older age groups. The …

Brown and brite adipocytes contribute to energy expenditure through nonshivering
thermogenesis. Though these cell types are thought to arise primarily from the de novo …

Beige adipocytes are transiently induced during early postnatal period in mice. Previous
studies have suggested that, unlike in adults, the induction is independent of the …

Susceptibility to obesity changes during the course of life. We utilized the C57 BL/6J (B6)
and 129S mouse as a genetic model for variation in diet‐induced obesity to define the …

The discovery of brown adipose tissue in adult humans along with the recognition of
adipocyte heterogeneity and plasticity of white fat depots has renewed the interest in …

Beige adipocytes are defined as Ucp1+, multilocular adipocytes within white adipose tissue
(WAT) that are capable of thermogenesis, the process of heat generation. In both mouse …

During the first month of postnatal life, adipose tissue depots of mice go through a drastic,
but transient, remodeling process. Between postnatal days 10 and 20, several white fat …

Adipose tissue development begins in the fetal period, and continues to expand after birth.
Dysregulation of adipose tissue during weaning may predispose individuals to lifelong …

Adipose tissue provides a defense against starvation and environmental cold. These
dichotomous functions are performed by three distinct cell types: energy-storing white …

Uncoupling protein 1+ beige adipocytes are dynamically regulated by environment in
rodents and humans; cold induces formation of beige adipocytes, whereas warm …