The clinical syndromes comprising urinary tract infection (UTI) continue to exert significant
impact on millions of patients worldwide, most of whom are otherwise healthy women …

Escherichia coli includes clonal groups of both commensal and pathogenic strains, with
some of the latter causing serious infectious diseases. O antigen variation is current …

The ATP-binding cassette (ABC) transporter superfamily is found in all domains of life,
facilitating critical biological processes through the translocation of a wide variety of …

Urinary tract infections (UTIs) are among the most common infections worldwide.
Uropathogenic Escherichia coli (UPECs) are the main causative agent of UTIs. UPECs …

Escherichia coli plays an important role as a member of the gut microbiota; however,
pathogenic strains also exist, including various diarrheagenic E. coli pathotypes and …

Background Escherichia coli infections are increasing worldwide in community and hospital
settings. The E coli O-antigen is a promising vaccine target. We aimed to assess the safety …

Cell surface carbohydrates have been proven optimal targets for vaccine development.
Conjugation of polysaccharides to a carrier protein triggers a T-cell-dependent immune …

Urinary tract infections (UTIs) belong to the most common infectious diseases worldwide.
The most frequently isolated pathogen from uncomplicated UTIs is Escherichia coli. To …

Programmable control over an addressable global regulator would enable simultaneous
repression of multiple genes and would have tremendous impact on the field of synthetic …

Healthcare-associated infections (HAIs) represent a burden for public health with a high
prevalence and high death rates associated with them. Pathogens with a high potential for …