In this Review, we explore natural product antibiotics that do more than simply inhibit an
active site of an essential enzyme. We review these compounds to provide inspiration for the …

Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

Cytochrome P450 enzymes (P450s) catalyze diverse oxidative cross-coupling reactions
between aromatic substrates in the natural product biosynthesis. Specifically, P450s install …

Darobactin is a heptapeptide antibiotic featuring an ether cross-link and a C–C cross-link,
and both cross-links are installed by a radical S-adenosylmethionine (rSAM) enzyme DarE …

Ribosomally synthesized and post‐translationally modified peptides (RiPPs) are a
fascinating group of natural products that exhibit diverse structural features and bioactivities …

Antimicrobial resistance (AMR) has become a major problem in public health leading to an
estimated 4.95 million deaths in 2019. The selective pressure caused by the massive and …

Antibiotics represent a frequently employed therapeutic modality for the management of
bacterial infections across diverse domains, including human health, agriculture, livestock …

There is a lack of new antibiotics to combat drug-resistant bacterial infections that
increasingly threaten global health. The current pipeline of clinical-stage antimicrobials is …

Cyclic peptide natural products represent an important class of bioactive compounds and
clinical drugs. Enzymatic side-chain macrocyclization of ribosomal peptides is a major …

The β‐barrel assembly machinery (BAM complex) is essential for outer membrane protein
(OMP) folding in Gram‐negative bacteria, and represents a promising antimicrobial target …