Cancer microenvironment is critical for tumorigenesis and cancer progression. The
extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells …

Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Crosstalk between ion channels and small GTPases is critical during homeostasis and
disease, but little is known about the structural underpinnings of these interactions. TRPV4 is …

Transient Receptor Potential (TRP) channels are a family of ion channels whose members
are distributed among all kinds of animals, from invertebrates to vertebrates. The importance …

Hypertensive heart disease constitutes functional and structural dysfunction and
pathogenesis occurring primarily in the left ventricle, the left atrium and the coronary arteries …

Overactive bladder syndrome with and without urinary incontinence and related conditions,
signs, and disorders such as detrusor overactivity, neurogenic lower urinary tract …

Inherited peripheral neuropathies are a genetically and phenotypically diverse group of
disorders that lead to degeneration of peripheral neurons with resulting sensory and motor …

Blood-CNS barrier disruption is a hallmark of numerous neurological disorders, yet whether
barrier breakdown is sufficient to trigger neurodegenerative disease remains unresolved …

Lethality of coronavirus disease (COVID-19) during the 2020 pandemic, currently still in the
exponentially accelerating phase in most countries, is critically driven by disruption of the …

Itch is an unpleasant sensation arising from a variety of dermatologic, neuropathic, systemic,
and psychogenic etiologies. Various itch pathways are implicated according to the …