Adipocytes were identified in human bone marrow more than a century ago, yet until
recently little has been known about their origin, development, function or interactions with …

Obesity, defined by an excess of adipose tissue, is often associated with the development of
various metabolic diseases. The increased and inappropriate deposition of this tissue …

Adiponectin is secreted from adipocytes, and low circulating levels have been
epidemiologically associated with obesity, insulin resistance, type 2 diabetes, and …

Adiponectin is a plasma protein expressed exclusively in adipose tissue. Adiponectin levels
are linked to insulin sensitivity, but a direct effect of chronically elevated adiponectin on …

Adiponectin has until now been considered to be synthesized and secreted exclusively by
the adipose tissue, and is reported to influence energy homeostasis and insulin sensitivity. It …

Background & Aims: Obesity is one of the risk factors for liver fibrosis, in which plasma
adiponectin, an adipocytokine, levels are decreased. Hepatic stellate cells play central roles …

Previous studies revealed that carboxyl-terminal fragment containing the globular domain of
adiponectin exists in human plasma. Although it is proposed that the globular fragment is …

Pathways leading from obesity to the manifestations of metabolic syndrome involve a
number of metabolic risk factors, as well as adipokines, mediators of inflammatory response …

Growing evidence suggests that positive associations between fat mass (FM) and bone
mineral density (BMD) are mediated by not only biomechanical but also biochemical factors …

Since interaction between bone and lipid metabolism has been suggested, this study
investigated the regulation of bone metabolism by adiponectin, a representative adipokine …