Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

Three dimensional bioprinting is an emerging fabrication technique in the field of tissue
engineering. Extrusion-based bioprinting is one of the widely employed biofabrication …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

The extracellular matrix is a complex network of hydrated macromolecular proteins and
sugars that, in concert with bound soluble factors, comprise the acellular stromal …

Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

The nuclear lamina is an important structural determinant for the nuclear envelope as a
whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear …

Research in cellular mechanotransduction often focuses on how extracellular physical
forces are converted into chemical signals at the cell surface. However, mechanical forces …

The nucleus is the largest organelle and is commonly depicted in the center of the cell. Yet
during cell division, migration, and differentiation, it frequently moves to an asymmetric …

Cells sense their physical surroundings through mechanotransduction—that is, by
translating mechanical forces and deformations into biochemical signals such as changes in …

Maintaining physical connections between the nucleus and the cytoskeleton is important for
many cellular processes that require coordinated movement and positioning of the nucleus …