Toll-like receptor signaling and its role in cell-mediated immunity
Innate immunity is the first defense system against invading pathogens. Toll-like receptors
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …
Can SARS-CoV-2 virus use multiple receptors to enter host cells?
LK Gadanec, KR McSweeney, T Qaradakhi… - International journal of …, 2021 - mdpi.com
The occurrence of the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-
2), responsible for coronavirus disease 2019 (COVD-19), represents a catastrophic threat to …
2), responsible for coronavirus disease 2019 (COVD-19), represents a catastrophic threat to …
The anti-inflammatory effect of taurine on cardiovascular disease
T Qaradakhi, LK Gadanec, KR McSweeney… - Nutrients, 2020 - mdpi.com
Taurine is a non-protein amino acid that is expressed in the majority of animal tissues. With
its unique sulfonic acid makeup, taurine influences cellular functions, including …
its unique sulfonic acid makeup, taurine influences cellular functions, including …
Leprosy in the 21st century
C White, C Franco-Paredes - Clinical microbiology reviews, 2015 - Am Soc Microbiol
Despite significant improvements in leprosy (Hansen's disease) treatment and outlook for
patients since the introduction of multidrug therapy (MDT) 3 decades ago, the global …
patients since the introduction of multidrug therapy (MDT) 3 decades ago, the global …
From evolutionary genetics to human immunology: how selection shapes host defence genes
LB Barreiro, L Quintana-Murci - Nature Reviews Genetics, 2010 - nature.com
Pathogens have always been a major cause of human mortality, so they impose strong
selective pressure on the human genome. Data from population genetic studies, including …
selective pressure on the human genome. Data from population genetic studies, including …
[HTML][HTML] The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans
Exposure to Mycobacterium tuberculosis produces varied early outcomes, ranging from
resistance to infection to progressive disease. Here we report results from a forward genetic …
resistance to infection to progressive disease. Here we report results from a forward genetic …
Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer
Since first being described in the fruit fly Drosophila melanogaster, Toll-like receptors (TLRs)
have proven to be of great interest to immunologists and investigators interested in the …
have proven to be of great interest to immunologists and investigators interested in the …
A review of human coronaviruses' receptors: the host-cell targets for the crown bearing viruses
A novel human coronavirus prompted considerable worry at the end of the year 2019. Now,
it represents a significant global health and economic burden. The newly emerged …
it represents a significant global health and economic burden. The newly emerged …
Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense
Infectious diseases have been paramount among the threats to health and survival
throughout human evolutionary history. Natural selection is therefore expected to act …
throughout human evolutionary history. Natural selection is therefore expected to act …
Leprosy: an overview of pathophysiology
RM Bhat, C Prakash - Interdisciplinary perspectives on …, 2012 - Wiley Online Library
Leprosy, also known as Hansen's disease, is a chronic infectious disease caused by
Mycobacterium leprae, a microorganism that has a predilection for the skin and nerves. The …
Mycobacterium leprae, a microorganism that has a predilection for the skin and nerves. The …