Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …

Multiple sclerosis (MS) is an autoimmune disease triggered by environmental factors that act
on a genetically susceptible host. It features three clinical stages: a pre-clinical stage …

B cells are essential components of the adaptive immune system and have important roles
in the pathogenesis of several central nervous system (CNS) diseases. Besides producing …

New evidence and consensus has led to further revision of the McDonald Criteria for
diagnosis of multiple sclerosis. The use of imaging for demonstration of dissemination of …

Astrocytes have complex roles in health and disease, thus it is important to study the
pathways that regulate their function. Here we report that lactosylceramide (LacCer) …

Dendritic cells (DCs) control the balance between effector T cells and regulatory T cells in
vivo. Hence, the study of DCs might identify mechanisms of disease pathogenesis and guide …

Background Multiple sclerosis is a chronic inflammatory demyelinating disease of the central
nervous system. Many findings suggest that the disease has an autoimmune pathogenesis; …

The immune response is normally controlled by regulatory T cells (Tregs). However, Treg
deficits are found in autoimmune diseases, and therefore the induction of functional Tregs is …

Therapeutic approaches for the induction of immune tolerance remain an unmet clinical
need for the treatment of autoimmune diseases, including multiple sclerosis (MS). Based on …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
which responds to anti-inflammatory treatments in the early disease phase. However, the …