Poxviruses (PXVs) are mostly known for the variola virus, being the cause of smallpox;
however, re-emerging PXVs have also shown a great capacity to develop outbreaks of pox …

Traumatic brain injury (TBI) can initiate a very complex disease of the central nervous
system (CNS), starting with the primary pathology of the inciting trauma and subsequent …

The pathogenesis of spinal cord injury (SCI) remains poorly understood and treatment
remains limited. Emerging evidence indicates that post-SCI inflammation is severe but the …

Serine protease inhibitors, SERPINS, are a highly conserved family of proteins that regulate
serine proteases in the central coagulation and immune pathways, representing 2–10% of …

A traumatic brain injury (TBI) initiates an inflammatory response with molecular cascades
triggered by the presence of necrotic debris, including damaged myelin, hemorrhages and …

Immunopathogenesis in systemic viral infections can induce a septic state with leaky
capillary syndrome, disseminated coagulopathy, and high mortality with limited treatment …

Spinal cord injury (SCI) results in massive secondary damage characterized by a prolonged
inflammation with phagocytic macrophage invasion and tissue destruction. In prior work …

A massive localized trauma to the spinal cord results in complex pathologic events driven by
necrosis and vascular damage which in turn leads to hemorrhage and edema. Severe …

Viruses are widely used as a platform for the production of therapeutics. Vaccines containing
live, dead and components of viruses, gene therapy vectors and oncolytic viruses are key …

Spinal cord injury (SCI) initiates a severe, destructive inflammation with pro-inflammatory,
CD68+/CD163−, phagocytic macrophages infiltrating the area of necrosis and hemorrhage …