The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes

JA Pearson, FS Wong, L Wen - Journal of autoimmunity, 2016 - Elsevier
Abstract Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic
infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing …

[PDF][PDF] Procoagulant activity during viral infections

S Subramaniam, I Scharrer - Front Biosci (Landmark Ed), 2018 - article.imrpress.com
Introduction 2.1. Tissue Factor (TF)-dependent activation of coagulation system 2.2.
Endothelial cells (ECs) directed Hemostasis 2.3. Virus life cycle 2.4. TLRs expression …

Coxsackievirus and type 1 diabetes: diabetogenic mechanisms and implications for prevention

A Carré, F Vecchio, M Flodström-Tullberg… - Endocrine …, 2023 - academic.oup.com
The evidence for an association between coxsackievirus B (CVB) infection, pancreatic islet
autoimmunity, and clinical type 1 diabetes is increasing. Results from prospective cohorts …

Coxsackievirus B vaccines prevent infection-accelerated diabetes in NOD mice and have no disease-inducing effect

VM Stone, M Butrym, MM Hankaniemi… - Diabetes, 2021 - Am Diabetes Assoc
Enteroviruses, including the Coxsackievirus Bs (CVB), have been implicated as causal
agents in human type 1 diabetes. Immunization of at-risk individuals with a CVB vaccine …

The role of the innate immune system in destruction of pancreatic beta cells in NOD mice and humans with type I diabetes

N Tai, FS Wong, L Wen - Journal of autoimmunity, 2016 - Elsevier
Abstract Type 1 diabetes (T1D) is an organ-specific autoimmune disease characterized by T
cell-mediated destruction of the insulin-producing pancreatic β cells. A combination of …

Norovirus changes susceptibility to type 1 diabetes by altering intestinal microbiota and immune cell functions

JA Pearson, N Tai, DK Ekanayake-Alper… - Frontiers in …, 2019 - frontiersin.org
Environmental factors contribute to Type 1 diabetes (T1D) susceptibility. The gut
microbiome, which includes bacteria, viruses, and fungi, contributes to this environmental …

Antibacterial microspheres with a bionic red-blood-cell like hollow structure and superior swelling recovery capacity for efficient traumatic hemostasis

LV Caili, X Zhou, P Wang, Z Wu, Z Jiao, M Guo… - Applied Materials …, 2022 - Elsevier
Broad interest in developing new commercial hemostatic agents has been widely aroused
for massive blood loss in terms of hospital surgery and on the battlefield. In this study, we …

TRIF deficiency protects non-obese diabetic mice from type 1 diabetes by modulating the gut microbiota and dendritic cells

E Gülden, C Chao, N Tai, JA Pearson, J Peng… - Journal of …, 2018 - Elsevier
The incidence of type 1 diabetes (T1D) is determined by both genetic and environmental
factors. In recent years, the gut microbiota have been identified to be an important …

Enteroviruses and T1D: is it the virus, the genes or both which cause T1D

S Geravandi, H Liu, K Maedler - Microorganisms, 2020 - mdpi.com
Type 1 diabetes (T1D) is a chronic autoimmune disorder that results from the selective
destruction of insulin-producing β-cells in the pancreas. Up to now, the mechanisms …

Innate viral receptor signaling determines type 1 diabetes onset

ZJ Morse, MS Horwitz - Frontiers in endocrinology, 2017 - frontiersin.org
Heritable susceptibility of the autoimmune disorder, type 1 diabetes (T1D), only partially
equates for the incidence of the disease. Significant evidence attributes several …