Accumulating evidence suggests that a high tumour burden has a negative effect on
anticancer immunity. The concept of tumour burden, simply defined as the total amount of …

Immuno-oncology has revolutionized cancer treatment and has opened up new
opportunities for developing vaccination methods. DNA-based cancer vaccines have …

Background Despite their revolutionary success in cancer treatment over the last decades,
immunotherapies encounter limitations in certain tumor types and patients. The efficacy of …

BCMA/CD3-targeting bispecific antibodies (BsAb) are a recently developed immunotherapy
class that shows potent tumor killing activity in multiple myeloma. Here, we investigated a …

Simple Summary Multiple myeloma, a cancer of the bone marrow, is the commonest cancer
of adults in the Western World. Therapies have advanced dramatically in recent years …

Sargassum horneri (SH) is a seaweed that has several features that benefit health. In this
study, we investigated the immune-enhancing effect of SH, focusing on the role of spleen …

Simple Summary Multiple myeloma is an incurable blood cancer caused by the malignant
transformation of immunoglobulin-producing plasma cells. The mechanisms leading to the …

Multiple myeloma (MM) is a hematologic malignancy characterized by excessive clonal
proliferation of plasma cells. The treatment of multiple myeloma presents a variety of unique …

From the 1960s to the early 2000s, alkylating agents (eg, melphalan, cyclophosphamide,
and bendamustine) remained a key component of standard therapy for newly-diagnosed or …

Simple Summary A common characteristic of multiple myeloma (MM) is the dysfunction of
patients' immune system, a condition termed immunosuppression. This state is mainly due to …