Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca2+] i).
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …

There is much evidence showing that some lethal ventricular arrhythmias arise from waves
of Ca2+ release from the sarcoplasmic reticulum (SR) that propagate along cardiac cells …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal
inherited arrhythmia syndrome in which drug therapy is often ineffective. We discovered that …

Cx43, a major cardiac connexin, forms precursor hemichannels that accrue at the
intercalated disc to assemble as gap junctions. While gap junctions are crucial for electrical …

Computational models of electrical activity and calcium signaling in cardiac myocytes are
important tools for understanding physiology. The sensitivity of these models to changes in …

Enhanced cardiac diastolic Ca leak from the sarcoplasmic reticulum (SR) ryanodine
receptor may reduce SR Ca content and contribute to arrhythmogenesis. We tested whether …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is linked to mutations in the
cardiac ryanodine receptor (RyR2) or calsequestrin. We recently found that the drug …

Altered Ca2+ homeostasis is a salient feature of heart disease, where the calcium release
channel ryanodine receptor (RyR) plays a major role. Accumulating data support the notion …

Strong emotion and mental stress are now recognized as playing a significant role in severe
and fatal ventricular arrhythmias. The mechanisms, although incompletely understood …

Diastolic waves of Ca2+ release have been shown to activate delayed afterdepolarizations
as well as some cardiac arrhythmias. The aim of this study was to investigate whether …