Ischemic heart disease (IHD) remains the leading cause of death and disability worldwide.
For patients presenting with an acute myocardial infarction, the most effective treatment for …

Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

The tumor microenvironment (TME) is an ensemble of non-tumor cells comprising
fibroblasts, cells of the immune system, and endothelial cells, besides various soluble …

In five large‐scale trials involving> 40 000 patients, sodium–glucose cotransporter 2
(SGLT2) inhibitors decreased the risk of serious heart failure events by 25–40%. This effect …

The experimental evidence supporting the mitochondrial permeability transition pore
(mPTP) as a major mediator of lethal myocardial reperfusion injury and therefore a critical …

Intracellular pH (pHi) is an important modulator of cardiac excitation and contraction, and a
potent trigger of electrical arrhythmia. This review outlines the intracellular and membrane …

Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for
metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis …

The pH gradient in normal cells is tightly controlled by the activity of various pH-regulatory
membrane proteins including the isoform protein of the Na+/H+ exchanger (NHE1). NHE1 is …

In 2002, Hoshijima and Chien drew largely theoretical parallels between the dysregulation
of the signaling pathways driving cancer and those driving cardiac hypertrophy (Hoshijima …

Acidosis is characteristic of the solid tumor microenvironment. Tumor cells, because they are
highly proliferative and anabolic, have greatly elevated metabolic acid production. To …