Heart failure (HF) is a clinical syndrome with high morbidity and mortality, and its prevalence
is rapidly increasing. Galectin-3 (Gal-3) is an important factor in the pathophysiology of HF …

Galectins are β-galactoside-binding proteins that bind and crosslink molecules via their
sugar moieties, forming signaling and adhesion networks involved in cellular …

The Wnt/β-catenin signaling pathway is a classical Wnt pathway that regulates the stability
and nuclear localization of β-catenin and plays an important role in adult heart development …

Irreversible cardiomyocyte death is one of the main reasons of heart failure following cardiac
injury. Therefore, controlling cardiomyocyte death is an effective method to delay the …

We previously documented that M2-like macrophages exert a hepatoprotective effect in
acute-on-chronic liver failure (ACLF) by inhibiting necroptosis signalling. Nevertheless, the …

Doxorubicin (DOXO) is an effective drug that is used in the treatment of a large number of
cancers. Regardless of its important chemotherapeutic characteristics, its usage is restricted …

Traumatic spinal cord injury (SCI) can lead to motor disturbance, sensory deficit, or
autonomic dysfunction. The role of circRNAs in the pivotal physiopathological processes of …

Abstract Background/Aims: Acute kidney injury (AKI) is a public health burden with
increasing morbidity, mortality and health care cost. It is associated with increased risk for …

A variety of G protein-coupled receptors (GPCRs) are involved in the regulation of
cardiovascular function. The β-adrenoceptors (β-ARs), with three subtypes, are the dominant …

Oral squamous cell carcinoma (OSCC) is a cancer associated with high mortality
(accounting for 3.1/100,000 deaths per year in Brazil in 2013) and a high frequency of …