Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …

The endoplasmic reticulum (ER) is a major organelle involved in protein quality control and
cellular homeostasis. ER stress results from structural and functional dysfunction of the …

Zebrafish are widely considered an excellent vertebrate model for studying the
pathogenesis of human diseases because of their transparency of embryonic development …

Amyotrophic lateral sclerosis (ALS) is a fatal, severely debilitating and rapidly progressing
disorder affecting motor neurons in the brain, brainstem, and spinal cord. Unfortunately …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a severe neurodegenerative disease
affecting motor neurons. Pathological forms of Tar-DNA binding protein-43 (TDP-43) …

The interplay between metal ion binding and the activity of thiol proteins, particularly within
the protein disulfide isomerase family, remains an area of active investigation due to the …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease with a
complex, multifactorial pathophysiology, most commonly manifest as loss of motor neurons …

Multiple sclerosis (MS), classically known as an autoimmune, demyelinating disease of the
central nervous system, has a significant neurodegenerative component which underlies …

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder that progresses rapidly
and affects motor neurons in the brain, brainstem and spinal cord. Pathological forms of TAR …

Gaucher disease (GD) is a recessive genetic lysosomal storage disorder caused by a
deficiency of the enzyme β-glucosidase. The resultant accumulation of its substrate …