Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

WZ Zhuang, YH Lin, LJ Su, MS Wu, HY Jeng… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy
because of their high immunomodulation ability, tropism towards inflamed and injured …

Multi-lineage human iPSC-derived platforms for disease modeling and drug discovery

A Sharma, S Sances, MJ Workman, CN Svendsen - Cell stem cell, 2020 - cell.com
Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease
modeling and have unlocked new possibilities for understanding the mechanisms governing …

The sodium/iodide symporter (NIS): molecular physiology and preclinical and clinical applications

S Ravera, A Reyna-Neyra, G Ferrandino… - Annual review of …, 2017 - annualreviews.org
Active iodide (I−) transport in both the thyroid and some extrathyroidal tissues is mediated by
the Na+/I− symporter (NIS). In the thyroid, NIS-mediated I− uptake plays a pivotal role in …

Electrical and mechanical stimulation of cardiac cells and tissue constructs

WL Stoppel, DL Kaplan, LD Black III - Advanced drug delivery reviews, 2016 - Elsevier
The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …

Pluripotent stem cells: current understanding and future directions

A Romito, G Cobellis - Stem cells international, 2016 - Wiley Online Library
Pluripotent stem cells have the ability to undergo self‐renewal and to give rise to all cells of
the tissues of the body. However, this definition has been recently complicated by the …

Clinical imaging in regenerative medicine

AV Naumova, M Modo, A Moore, CE Murry… - Nature …, 2014 - nature.com
In regenerative medicine, clinical imaging is indispensable for characterizing damaged
tissue and for measuring the safety and efficacy of therapy. However, the ability to track the …

Stem cell imaging: from bench to bedside

PK Nguyen, J Riegler, JC Wu - Cell stem cell, 2014 - cell.com
Although cellular therapies hold great promise for the treatment of human disease, results
from several initial clinical trials have not shown a level of efficacy required for their use as a …

Preclinical studies of stem cell therapy for heart disease

BA Tompkins, W Balkan, J Winkler… - Circulation …, 2018 - Am Heart Assoc
As part of the TACTICS (Transnational Alliance for Regenerative Therapies in
Cardiovascular Syndromes) series to enhance regenerative medicine, here, we discuss the …

Advanced good cell culture practice for human primary, stem cell-derived and organoid models as well as microphysiological systems

D Pamies, AK Bal-Price, C Chesné, S Coecke… - 2018 - kops.uni-konstanz.de
A major reason for the current reproducibility crisis in the life sciences is the poor
implementation of quality control measures and reporting standards. Improvement is …

Pathophysiology of ST-segment elevation myocardial infarction: novel mechanisms and treatments

F Montecucco, F Carbone… - European heart …, 2016 - academic.oup.com
Despite major advances in mechanical and pharmacological reperfusion strategies to
improve acute myocardial infarction (MI) injury, substantial mortality, morbidity, and …