Long-term survival after kidney transplantation

S Hariharan, AK Israni… - New England Journal of …, 2021 - Mass Medical Soc
Long-Term Survival after Kidney Transplantation This review discusses demographics,
survival, and risks in kidney transplantation since the mid-1990s. It addresses postoperative …

The therapeutic challenge of late antibody‐mediated kidney allograft rejection

GA Böhmig, F Eskandary, K Doberer… - Transplant …, 2019 - Wiley Online Library
Late antibody‐mediated rejection (ABMR) is a cardinal cause of kidney allograft failure,
manifesting as a continuous and, in contrast with early rejection, often clinically silent …

C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates

R Schmitz, ZW Fitch, PM Schroder, AY Choi… - Nature …, 2021 - nature.com
Sensitized kidney transplant recipients experience high rates of antibody-mediated rejection
due to the presence of donor-specific antibodies and immunologic memory. Here we show …

Daratumumab in sensitized kidney transplantation: potentials and limitations of experimental and clinical use

J Kwun, M Matignon, M Manook… - Journal of the …, 2019 - journals.lww.com
Background Donor-specific antibodies are associated with increased risk of antibody-
mediated rejection and decreased allograft survival. Therefore, reducing the risk of these …

Emerging drugs for antibody-mediated rejection after kidney transplantation: a focus on phase II & III trials

KA Mayer, K Budde, B Jilma, K Doberer… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Antibody-mediated rejection (ABMR) is a leading cause of kidney allograft
failure. Its therapy continues to be challenge, and no treatment has been approved for the …

Emerging new approaches in desensitization: targeted therapies for HLA sensitization

AY Choi, M Manook, D Olaso, B Ezekian… - Frontiers in …, 2021 - frontiersin.org
There is an urgent need for therapeutic interventions for desensitization and antibody-
mediated rejection (AMR) in sensitized patients with preformed or de novo donor-specific …

Recent progress and remaining hurdles toward clinical xenotransplantation

RPH Meier, A Longchamp, M Mohiuddin… - …, 2021 - Wiley Online Library
Background Xenotransplantation has made tremendous progress over the last decade.
Methods We discuss kidney and heart xenotransplantation, which are nearing initial clinical …

[HTML][HTML] Reversing donor-specific antibody responses and antibody-mediated rejection with bortezomib and belatacept in mice and kidney transplant recipients

D Jain, A Rajab, JS Young, D Yin, T Nadasdy… - American Journal of …, 2020 - Elsevier
Active antibody-mediated rejection (AMR) is a potentially devastating complication and
consistently effective treatment remains elusive. We hypothesized that the reversal of acute …

Pretransplant desensitization with costimulation blockade and proteasome inhibitor reduces DSA and delays antibody-mediated rejection in highly sensitized …

B Ezekian, PM Schroder, MS Mulvihill… - Journal of the …, 2019 - journals.lww.com
Background Patients with broad HLA sensitization have poor access to donor organs, high
mortality while waiting for kidney transplant, and inferior graft survival. Although …

What have we learned about how to prevent and treat antibody‐mediated rejection in kidney transplantation?

PW Nickerson - American Journal of Transplantation, 2020 - Wiley Online Library
Antibody‐mediated rejection (ABMR) in kidney transplantation is a major cause of late graft
loss, and despite all efforts to date the “standard of care” remains plasmapheresis, IVIg, and …