Long-term survival after kidney transplantation
S Hariharan, AK Israni… - New England Journal of …, 2021 - Mass Medical Soc
Long-Term Survival after Kidney Transplantation This review discusses demographics,
survival, and risks in kidney transplantation since the mid-1990s. It addresses postoperative …
survival, and risks in kidney transplantation since the mid-1990s. It addresses postoperative …
The therapeutic challenge of late antibody‐mediated kidney allograft rejection
GA Böhmig, F Eskandary, K Doberer… - Transplant …, 2019 - Wiley Online Library
Late antibody‐mediated rejection (ABMR) is a cardinal cause of kidney allograft failure,
manifesting as a continuous and, in contrast with early rejection, often clinically silent …
manifesting as a continuous and, in contrast with early rejection, often clinically silent …
C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates
Sensitized kidney transplant recipients experience high rates of antibody-mediated rejection
due to the presence of donor-specific antibodies and immunologic memory. Here we show …
due to the presence of donor-specific antibodies and immunologic memory. Here we show …
Daratumumab in sensitized kidney transplantation: potentials and limitations of experimental and clinical use
J Kwun, M Matignon, M Manook… - Journal of the …, 2019 - journals.lww.com
Background Donor-specific antibodies are associated with increased risk of antibody-
mediated rejection and decreased allograft survival. Therefore, reducing the risk of these …
mediated rejection and decreased allograft survival. Therefore, reducing the risk of these …
Emerging drugs for antibody-mediated rejection after kidney transplantation: a focus on phase II & III trials
Introduction Antibody-mediated rejection (ABMR) is a leading cause of kidney allograft
failure. Its therapy continues to be challenge, and no treatment has been approved for the …
failure. Its therapy continues to be challenge, and no treatment has been approved for the …
Emerging new approaches in desensitization: targeted therapies for HLA sensitization
There is an urgent need for therapeutic interventions for desensitization and antibody-
mediated rejection (AMR) in sensitized patients with preformed or de novo donor-specific …
mediated rejection (AMR) in sensitized patients with preformed or de novo donor-specific …
Recent progress and remaining hurdles toward clinical xenotransplantation
Background Xenotransplantation has made tremendous progress over the last decade.
Methods We discuss kidney and heart xenotransplantation, which are nearing initial clinical …
Methods We discuss kidney and heart xenotransplantation, which are nearing initial clinical …
[HTML][HTML] Reversing donor-specific antibody responses and antibody-mediated rejection with bortezomib and belatacept in mice and kidney transplant recipients
Active antibody-mediated rejection (AMR) is a potentially devastating complication and
consistently effective treatment remains elusive. We hypothesized that the reversal of acute …
consistently effective treatment remains elusive. We hypothesized that the reversal of acute …
Pretransplant desensitization with costimulation blockade and proteasome inhibitor reduces DSA and delays antibody-mediated rejection in highly sensitized …
B Ezekian, PM Schroder, MS Mulvihill… - Journal of the …, 2019 - journals.lww.com
Background Patients with broad HLA sensitization have poor access to donor organs, high
mortality while waiting for kidney transplant, and inferior graft survival. Although …
mortality while waiting for kidney transplant, and inferior graft survival. Although …
What have we learned about how to prevent and treat antibody‐mediated rejection in kidney transplantation?
PW Nickerson - American Journal of Transplantation, 2020 - Wiley Online Library
Antibody‐mediated rejection (ABMR) in kidney transplantation is a major cause of late graft
loss, and despite all efforts to date the “standard of care” remains plasmapheresis, IVIg, and …
loss, and despite all efforts to date the “standard of care” remains plasmapheresis, IVIg, and …