Wnt signaling through the canonical β-catenin pathway plays essential roles in development
and disease. L ow-density-lipoprotein receptor-r elated p roteins 5 and 6 (Lrp5 and Lrp6) in …

Osteosarcoma is the most common nonhematologic malignancy of bone in children and
adults. The peak incidence occurs in the second decade of life, with a smaller peak after age …

Based on the fact that aging is associated with a reciprocal decrease of osteogenesis and
an increase of adipogenesis in bone marrow and that osteoblasts and adipocytes share a …

LDL receptor related proteins 5 and 6 (LRP5/6) and their Drosophila homolog Arrow are
single-span transmembrane proteins essential for Wnt/β-catenin signaling, likely via acting …

Previous studies have associated activation of canonical Wnt signaling in osteoblasts with
elevated bone formation. Here we report that deletion of the murine Wnt antagonist, secreted …

COPD and osteoporosis are strongly associated because of common risk factors such as
age, smoking, and inactivity. In addition, COPD-related systemic inflammation, vitamin D …

Reports implicating Wnt signalling in the regulation of bone mass have prompted
widespread interest in the use of Wnt mimetics for the treatment of skeletal disorders. To …

Bone morphogenetic proteins (BMPs) are known to induce ectopic bone. However, it is
largely unknown how BMP signaling in osteoblasts directly regulates endogenous bone …

In the aorta, diabetes activates an osteogenic program that includes expression of bone
morphogenetic protein-2 (BMP2) and the osteoblast homeoprotein Msx2. To evaluate BMP2 …

Recent work has identified LDL receptor-related family members, Lrp5 and Lrp6, as co-
receptors for the transduction of Wnt signals. Our analysis of mice carrying mutations in both …