Clinical development of metal complexes as photosensitizers for photodynamic therapy of cancer

J Karges - Angewandte Chemie International Edition, 2022 - Wiley Online Library
Cancer has emerged over the last decades as one of the deadliest diseases in the world.
Among the most commonly used techniques (ie surgery, immunotherapy, radiotherapy or …

Overcoming the Achilles' heel of photodynamic therapy

W Fan, P Huang, X Chen - Chemical Society Reviews, 2016 - pubs.rsc.org
Photodynamic therapy (PDT) has been applied to treat a wide range of medical conditions,
including wet age-related macular degeneration psoriasis, atherosclerosis, viral infection …

Biofilm‐sensitive photodynamic nanoparticles for enhanced penetration and antibacterial efficiency

S Wu, C Xu, Y Zhu, L Zheng, L Zhang… - Advanced Functional …, 2021 - Wiley Online Library
Efficient antimicrobials are urgently needed for the treatment of bacterial biofilms due to their
resistance to traditional drugs. Photodynamic therapy (PDT) is a new strategy that has been …

Critical overview of the use of Ru (II) polypyridyl complexes as photosensitizers in one-photon and two-photon photodynamic therapy

F Heinemann, J Karges, G Gasser - Accounts of chemical …, 2017 - ACS Publications
Conspectus Photodynamic Therapy (PDT) is an emerging technique to treat certain types of
cancer, bacterial, fungal, and viral infections, and skin diseases. In past years, different …

Recent advances in photonanomedicines for enhanced cancer photodynamic therapy

JJ Hu, Q Lei, XZ Zhang - Progress in Materials Science, 2020 - Elsevier
Nowadays, photodynamic therapy (PDT) that employs photosensitizers (PSs) to generate
cytotoxic species under light irradiation for selective destruction of neoplastic lesions has …

Photosensitization and controlled photosensitization with BODIPY dyes

A Turksoy, D Yildiz, EU Akkaya - Coordination Chemistry Reviews, 2019 - Elsevier
Highly versatile BODIPY dyes proved themselves to be very useful as photosensitizers.
These dyes can be derivatized to absorb essentially anywhere in the visible the near IR …

Reduction of Platinum (IV) Prodrug Hemoglobin Nanoparticles with Deeply Penetrating Ultrasound Radiation for Tumor‐Targeted Therapeutically Enhanced …

G Liang, T Sadhukhan, S Banerjee… - Angewandte Chemie …, 2023 - Wiley Online Library
The development of PtIV prodrugs that are reduced into the therapeutically active PtII
species within the tumor microenvironment has received much research interest. In order to …

A Multi‐action and Multi‐target RuII–PtIV Conjugate Combining Cancer‐Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers

J Karges, T Yempala, M Tharaud… - Angewandte Chemie …, 2020 - Wiley Online Library
PtII complexes are commonly used to treat cancer. To reduce their side effects and improve
their pharmacological properties, PtIV complexes are being developed as prodrug …

Rationally designed long-wavelength absorbing Ru (II) polypyridyl complexes as photosensitizers for photodynamic therapy

J Karges, F Heinemann, M Jakubaszek… - Journal of the …, 2020 - ACS Publications
The utilization of photodynamic therapy (PDT) for the treatment of various types of cancer
has gained increasing attention over the last decades. Despite the clinical success of …

[HTML][HTML] Advance in photosensitizers and light delivery for photodynamic therapy

I Yoon, JZ Li, YK Shim - Clinical endoscopy, 2013 - ncbi.nlm.nih.gov
The brief history of photodynamic therapy (PDT) research has been focused on
photosensitizers (PSs) and light delivery was introduced recently. The appropriate PSs were …