The treatment of bone defects remains a challenging clinical problem with high
reintervention rates, morbidity, and resulting significant healthcare costs. Surgical …

Life sciences are currently facing a reproducibility crisis. Originally, the crisis was born out of
single alarming failures to reproduce findings at different times and locations. Nowadays …

Center for Open Science, Charlottesville, Virginia, USA. Research is cumulative. New
investigations build on, challenge, or qualify claims based on prior evidence. When we have …

Introduction Translation is about successfully bringing findings from preclinical contexts into
the clinic. This transfer is challenging as clinical trials frequently fail despite positive …

Background The deployment of bone grafts (BGs) is critical to the success of scaffold-guided
bone regeneration (SGBR) of large bone defects. It is thus critical to provide harvesting …

Flavonoids are natural secondary compounds of plants with a basic composition derived
from polyphenols that can produce a plethora of different neurochemical effects, some of …

This booklet is a user guide for experimenters who intend to carry out an animal trial and
seek to obtain ethics approval from regulatory authorities. It is also meant to aid scientists …