Across complex, multi-time and-length scale biological systems, redundancy confers
robustness and resilience, enabling adaptation and increasing survival under dynamic …

Beneficial properties of mesenchymal stromal cells (MSCs) have prompted their use in
preclinical and clinical research. Accumulating evidence has been provided for the …

Mesenchymal stem cells (MSCs) secrete paracrine factors that play crucial roles during
tissue regeneration. An increasing body of evidence suggests that this paracrine function is …

Cells are able to perceive complex mechanical cues from their microenvironment, which in
turn influences their development. Although the understanding of these intricate …

Biophysical properties of the cellular microenvironment, including stiffness and geometry,
have been shown to influence cell function. Recent findings have implicated 3D confinement …

Generating skeletal muscle tissue that mimics the cellular alignment, maturation, and
function of native skeletal muscle is an ongoing challenge in disease modeling and …

Tendon is a highly organized tissue that transmits forces between muscle and bone. The
architecture of the extracellular matrix of tendon, predominantly from collagen type I, is …

Mesenchymal stem/stromal cells (MSCs) are a heterogenous population of multipotent and
highly secretory cells currently being investigated in the field of wound healing for their …

Aquaporins (AQPs) are a family of membrane water channel proteins that control osmotically-
driven water transport across cell membranes. Recent studies have focused on the …

Regeneration of tissues represents a current challenge and a need to treat damage and
diseased organs, and is becoming determinant to alleviate the burden of healthcare systems …