Inositols: from established knowledge to novel approaches

S Dinicola, V Unfer, F Facchinetti, CO Soulage… - International Journal of …, 2021 - mdpi.com
Myo-inositol (myo-Ins) and D-chiro-inositol (D-chiro-Ins) are natural compounds involved in
many biological pathways. Since the discovery of their involvement in endocrine signal …

Potential role and therapeutic interests of myo-inositol in metabolic diseases

ML Croze, CO Soulage - Biochimie, 2013 - Elsevier
Several inositol isomers and in particular myo-inositol (MI) and D-chiro-inositol (DCI), were
shown to possess insulin-mimetic properties and to be efficient in lowering post-prandial …

Mitochondria functionality and sperm quality

A Amaral, B Lourenço, M Marques… - …, 2013 - rep.bioscientifica.com
Although mitochondria are best known for being the eukaryotic cell powerhouses, these
organelles participate in various cellular functions besides ATP production, such as calcium …

Evaluation of sperm mitochondrial function: a key organelle for sperm motility

F Barbagallo, S La Vignera, R Cannarella… - Journal of Clinical …, 2020 - mdpi.com
Introduction: The role of nutraceuticals in the treatment of male infertility, especially in the
“idiopathic form”, remains the subject of significant debate. Many antioxidants improve …

Oxidative stress and male fertility: role of antioxidants and inositols

MN De Luca, M Colone, R Gambioli, A Stringaro… - Antioxidants, 2021 - mdpi.com
Infertility is defined as a couple's inability to conceive after at least one year of regular
unprotected intercourse. This condition has become a global health problem affecting …

Pharmacodynamics and pharmacokinetics of inositol (s) in health and disease

M Bizzarri, A Fuso, S Dinicola, A Cucina… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Inositol and its derivatives comprise a huge field of biology. Myo-inositol is not
only a prominent component of membrane-incorporated phosphatidylinositol, but …

Causes and consequences of sperm mitochondrial dysfunction

D Durairajanayagam, D Singh, A Agarwal… - Andrologia, 2021 - Wiley Online Library
Mitochondria have multiple functions, including synthesis of adenine triphosphate,
production of reactive oxygen species, calcium signalling, thermogenesis and apoptosis …

Myo-inositol in assisted reproductive technology from bench to bedside

A Etrusco, AS Laganà, V Chiantera… - Trends in Endocrinology …, 2024 - cell.com
Inositols are insulin-sensitizing compounds of promising efficacy in the management of
polycystic ovary syndrome (PCOS). On the one hand, myo-inositol (myo-ins) plays a …

Oxidative stress and male infertility: the protective role of antioxidants

A Kaltsas - Medicina, 2023 - mdpi.com
Oxidative stress is a significant factor in male infertility, compromising sperm function and
overall reproductive health. As male infertility garners increasing attention, effective …

[HTML][HTML] Role of antioxidants in fertility preservation of sperm—A narrative review

AY Qamar, MI Naveed, S Raza, X Fang, PK Roy… - Animal …, 2023 - ncbi.nlm.nih.gov
Male fertility is affected by multiple endogenous stressors, including reactive oxygen species
(ROS), which greatly deteriorate the fertility. However, physiological levels of ROS are …