The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …

The spatial separation of DNA replication and gene transcription in the nucleus and protein
translation in the cytoplasm is a uniform principle of eukaryotic cells. This …

ABSTRACT RIG-I-like receptors (RLRs) MDA5 and RIG-I are key players in the innate
antiviral response. Upon recognition of viral RNA, they interact with MAVS, eventually …

Amassments of heterochromatin in somatic cells occur in close contact with the nuclear
envelope (NE) but are gapped by channel‐and cone‐like zones that appear largely free of …

The nuclear pore complex is the sole gateway connecting the nucleoplasm and cytoplasm.
In humans, the nuclear pore complex is one of the largest multiprotein assemblies in the cell …

The movement of proteins between the cytoplasm and the nucleus conventionally involves
the recognition of nuclear targeting signals by members of the importin (Imp) superfamily of …

Trafficking of proteins and RNA into and out of the nucleus occurs through the nuclear pore
complex (NPC). Because of its critical function in many cellular processes, the NPC and …

During picornavirus infection, several cellular proteins are cleaved by virus-encoded
proteinases. Such cleavage events are likely to be involved in the changing dynamics …

Poliovirus disrupts nucleocytoplasmic trafficking and results in the cleavage of two nuclear
pore complex (NPC) proteins, Nup153 and Nup62. The NPC is a 125-MDa complex …

The present global COVID-19 pandemic caused by the noble pleomorphic severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a vulnerable situation in the …