Biomolecular condensates regulate transcription by dynamically compartmentalizing the
transcription machinery. Classic models of transcription regulation focus on the recruitment …

Abstract RNA polymerase II (Pol II) is the multi-protein complex responsible for transcribing
all protein-coding messenger RNA (mRNA). Most research on gene regulation is focused on …

In anamniote embryos, the major wave of zygotic genome activation starts during the mid-
blastula transition. However, some genes escape global genome repression, are activated …

Zygotic genome activation (ZGA) in the development of flies, fish, frogs and mammals
depends on pioneer-like transcription factors (TFs). Those TFs create open chromatin …

The eukaryotic genome is organized to enable the precise regulation of gene expression.
This organization is established as the embryo transitions from a fertilized gamete to a …

Binding of transcription factors (TFs) promotes the subsequent recruitment of coactivators
and preinitiation complexes to initiate eukaryotic transcription, but this time course is usually …

The localization of transcriptional activity in specialized transcription bodies is a hallmark of
gene expression in eukaryotic cells. 1–3 How proteins of the transcriptional machinery come …

Collisions between transcribing RNA polymerases and DNA replication forks are disruptive.
The threat of collisions is particularly acute during the rapid early embryonic cell cycles of …

In most species, the earliest stages of embryogenesis are characterized by rapid
proliferation, which must be tightly controlled with other cellular processes across the large …

Nanoscale chromatin organization regulates gene expression. Although chromatin is
notably reprogrammed during zygotic genome activation (ZGA), the organization of …