Purinergic signalling is involved in a number of physiological and pathophysiological
activities in the lower urinary tract. In the bladder of laboratory animals there is …

The lower urinary tract is a muscular system composed of the urinary bladder and the
outflow tract. During filling with urine the bladder is relaxed and the outflow tract offers a high …

Activation of afferent nerves during urinary bladder (UB) filling conveys the sensation of UB
fullness to the central nervous system (CNS). Although this sensory outflow is presumed to …

We developed a mathematical model to simulate the dynamics of background synaptic
noise in non-neuronal cells. By employing the stochastic Ornstein–Uhlenbeck process, we …

The role of adenosine 5′-triphosphate (ATP) as a major intracellular energy source is well-
established. In addition, ATP and related nucleotides have widespread extracellular actions …

The past half century has witnessed tremendous advances in our understanding of
extracellular purinergic signaling pathways. Purinergic neurotransmission, in particular, has …

P2X1 receptors are adenosine triphosphate (ATP)-gated cation channels that are
functionally important for male fertility, bladder contraction, and platelet aggregation. The …

The field of bladder research has been energized by the study of novel interstitial cells (IC)
over the last decade. Several subgroups of IC are located within the bladder wall and make …

The aim of this review is to describe the conceptual steps contributing to our current
knowledge of purinergic signalling and to consider its involvement in the physiology and …

The urinary bladder has two functions: to store urine, when it is relaxed and highly
compliant; and void its contents, when intravesical pressure rises due to co-ordinated …