Compounds having cyclic molecular frameworks are highly regarded for their abundance
and diverse utilities. In particular, medium-sized carbocycles and heterocycles exist in a …

Medium-sized rings have much promise in medicinal chemistry, but are difficult to make
using direct cyclisation methods. In this minireview, we highlight the value of ring expansion …

Photocatalytic generation of phosphoranyl radicals is fast emerging as an essential method
for the generation of diverse and valuable radicals, typically via deoxygenation or …

Palladium-catalyzed cycloaddition reactions via Pd-π-allyl zwitterions have been
established as significant synthetic transformations to enable numerous carbon-or …

Macrocycles and medium-sized rings are important in many scientific fields and
technologies but are hard to make using current methods, especially on a large scale …

The synthesis of medium-sized lactams is a great challenge because of the unfavorable
transannular interactions and entropic barriers in the transition state. We have developed a …

A catalyst-free, direct electrochemical synthesis of synthetically challenging medium-sized
lactams through C–C bond cleavage has been developed. In contrast to previous typical …

There are few enantioconvergent reactions in which racemic substrates bearing multiple
stereochemical features are converted into products with high levels of diastereo-and …

The steric-switched ipso-defluoroamination-triggered and ipso-defluorooxylation-triggered
cyclization of (trifluoromethyl) alkenes with amino alcohols and diamines are achieved …

N-Fused 5/7-membered bicycles have witnessed apparent importance in many bioactive
molecules, but there are rare examples to construct these privileged scaffolds by asymmetric …