Iron storage proteins are essential for the survival and pathogenesis of Mycobacterium tuberculosis in THP-1 macrophages and the guinea pig model of infection
PV Reddy, RV Puri, A Khera, AK Tyagi - Journal of bacteriology, 2012 - Am Soc Microbiol
Iron is one of the crucial elements required for the growth of Mycobacterium tuberculosis.
However, excess free iron becomes toxic for the cells because it catalyzes the production of …
However, excess free iron becomes toxic for the cells because it catalyzes the production of …
Signalling mechanisms in Mycobacteria
The importance of inter-and intracellular signal transduction in all forms of life cannot be
underestimated. A large number of genes dedicated to cellular signalling are found in …
underestimated. A large number of genes dedicated to cellular signalling are found in …
Comprehensive insights into Mycobacterium tuberculosis DevR (DosR) regulon activation switch
DevR regulon function is believed to be crucial for the survival of Mycobacterium
tuberculosis during dormancy. In this study, we undertook a comprehensive analysis of the …
tuberculosis during dormancy. In this study, we undertook a comprehensive analysis of the …
[HTML][HTML] Appropriate DevR (DosR)-Mediated Signaling Determines Transcriptional Response, Hypoxic Viability and Virulence of Mycobacterium tuberculosis
Background The DevR (DosR) regulon is implicated in hypoxic adaptation and virulence of
Mycobacterium tuberculosis. The present study was designed to decipher the impact of …
Mycobacterium tuberculosis. The present study was designed to decipher the impact of …
DNA Aptamer Targets Mycobacterium tuberculosis DevR/DosR Response Regulator Function by Inhibiting Its Dimerization and DNA Binding Activity
Tuberculosis is recognized as one of the major public health threats worldwide. The DevR–
DevS (DosR/DosS) two-component system is considered a novel drug target in …
DevS (DosR/DosS) two-component system is considered a novel drug target in …
[HTML][HTML] DevR (DosR) mimetic peptides impair transcriptional regulation and survival of Mycobacterium tuberculosis under hypoxia by inhibiting the autokinase …
Background Two-component systems have emerged as compelling targets for antibacterial
drug design for a number of reasons including the distinct histidine phosphorylation property …
drug design for a number of reasons including the distinct histidine phosphorylation property …
[HTML][HTML] Interplay of PhoP and DevR response regulators defines expression of the dormancy regulon in virulent Mycobacterium tuberculosis
The DevR response regulator of Mycobacterium tuberculosis is an established regulator of
the dormancy response in mycobacteria and can also be activated during aerobic growth …
the dormancy response in mycobacteria and can also be activated during aerobic growth …
Cognate sensor kinase‐independent activation of Mycobacterium tuberculosis response regulator DevR (DosR) by acetyl phosphate: implications in anti …
Summary The DevRS/DosT two‐component system is essential for mycobacterial survival
under hypoxia, a prevailing stress within granulomas. DevR (also known as DosR) is …
under hypoxia, a prevailing stress within granulomas. DevR (also known as DosR) is …
DevR (DosR) binding peptide inhibits adaptation of Mycobacterium tuberculosis under hypoxia
DevR is a key regulator of the dormancy response in Mycobacterium tuberculosis (M. tb).
Using DevR as bait to screen a phage display library, a peptide, DevRS1, was obtained …
Using DevR as bait to screen a phage display library, a peptide, DevRS1, was obtained …
Sustained expression of DevR/DosR during long-term hypoxic culture of Mycobacterium tuberculosis
DevR/DosR is a key mediator of 'dormancy'adaptation in Mycobacterium tuberculosis in
response to gaseous stresses such as hypoxia that inhibit aerobic mode of respiration. In the …
response to gaseous stresses such as hypoxia that inhibit aerobic mode of respiration. In the …