Immune memory is a defining feature of the acquired immune system, but activation of the
innate immune system can also result in enhanced responsiveness to subsequent triggers …

The mechanisms underlying innate immune memory have been extensively explored in the
last decades but are in fact largely unknown. Although the specificity of adaptive immune …

Innate immune cells can develop long-term memory after stimulation by microbial products
during infections or vaccinations. Here, we report that metabolic signals can induce trained …

Here, we report that functional heterogeneity of macrophages in cancer could be determined
by the nature of their precursors: monocytes (Mons) and monocytic myeloid-derived …

Antimicrobial resistance (AMR) is a growing threat to global public health, and the overuse
of antibiotics in animals has been identified as a major risk factor. With high levels of …

Over the last decades, there was increasing evidence for the presence of innate immune
memory in living organisms. In this review, we compare the innate immune memory of …

The ability of developing immunological memory, a characteristic feature of adaptive
immunity, is clearly present also in innate immune responses. In fact, it is well known that …

During induction of trained immunity, monocytes and macrophages undergo a functional
and transcriptional reprogramming toward increased activation. Important rewiring of cellular …

Background The interaction of organisms with their surrounding microbial communities
influences many biological processes, a notable example of which is the shaping of the …

Trans-generational immune priming (TGIP) refers to the transfer of the parental
immunological experience to its progeny. This may result in offspring protection from …