Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and
contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular …

Beige fat plays key roles in the regulation of systemic energy homeostasis; however,
detailed mechanisms and safe strategy for its activation remain elusive. In this study, we …

Diabetes mellitus (DM) is a collection of metabolic and pathophysiological disorders
manifested with high glucose levels in the blood due to the inability of β-pancreatic cells to …

Obesity and ageing place a tremendous strain on the global healthcare system. Age-related
sarcopenia is characterized by decreased muscular strength, decreased muscle quantity …

Viral vectors have been used for a broad spectrum of gene therapy for both acute and
chronic diseases. In the context of cancer gene therapy, viral vectors expressing anti-tumor …

The rising global prevalence of obesity, metabolic syndrome, and type 2 diabetes has driven
a sharp increase in non-alcoholic fatty liver disease (NAFLD), characterized by excessive fat …

Fibroblast growth factor 21 (FGF21) is a hormone that regulates important metabolic
pathways. FGF21 is expressed in several metabolically active organs and interacts with …

Sarcopenic obesity is defined as a multifactorial disease in aging with decreased body
muscle, decreased muscle strength, decreased independence, increased fat mass, due to …

Lifestyle modifications focused on healthy eating and regular exercise are the primary
recommendations for patients with nonalcoholic steatohepatitis (NASH). However, for …