[HTML][HTML] Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens
RA Quinlan, JI Clark - Journal of Biological Chemistry, 2022 - ASBMB
In the human eye, a transparent cornea and lens combine to form the" refracton" to focus
images on the retina. This requires the refracton to have a high refractive index" n," mediated …
images on the retina. This requires the refracton to have a high refractive index" n," mediated …
[HTML][HTML] Association of alpha-crystallin with fiber cell plasma membrane of the eye lens accompanied by light scattering and cataract formation
α-crystallin is a major protein found in the mammalian eye lens that works as a molecular
chaperone by preventing the aggregation of proteins and providing tolerance to stress in the …
chaperone by preventing the aggregation of proteins and providing tolerance to stress in the …
[HTML][HTML] Influence of cholesterol on the oxygen permeability of membranes: insight from atomistic simulations
Cholesterol is widely known to alter the physical properties and permeability of membranes.
Several prior works have implicated cell membrane cholesterol as a barrier to tissue …
Several prior works have implicated cell membrane cholesterol as a barrier to tissue …
[HTML][HTML] Solid lipid nanoparticles for dibucaine sustained release
Dibucaine (DBC) is among the more potent long-acting local anesthetics (LA), and it is also
one of the most toxic. Over the last decades, solid lipid nanoparticles (SLN) have been …
one of the most toxic. Over the last decades, solid lipid nanoparticles (SLN) have been …
Changes in the properties and organization of human lens lipid membranes occurring with age
Purpose: This research was undertaken to document the changes in the organization and
properties of human lens lipid membranes that occur with age. Methods: Human lens lipid …
properties of human lens lipid membranes that occur with age. Methods: Human lens lipid …
[HTML][HTML] Mechanical properties of the high cholesterol-containing membrane: An AFM study
Cholesterol (Chol) content in most cellular membranes does not exceed 50 mol%, only in
the eye lens's fiber cell plasma membrane, its content surpasses 50 mol%. At this high …
the eye lens's fiber cell plasma membrane, its content surpasses 50 mol%. At this high …
Properties of membranes derived from the total lipids extracted from the human lens cortex and nucleus
The organization and physical properties of lens lipid membranes made from the total lipids
extracted from the human lens cortex and nucleus of 41-to 60-year-old donors were …
extracted from the human lens cortex and nucleus of 41-to 60-year-old donors were …
Formation of cholesterol bilayer domains precedes formation of cholesterol crystals in cholesterol/dimyristoylphosphatidylcholine membranes: EPR and DSC studies
Saturation-recovery EPR along with DSC were used to determine the cholesterol content at
which pure cholesterol bilayer domains (CBDs) and cholesterol crystals begin to form in …
which pure cholesterol bilayer domains (CBDs) and cholesterol crystals begin to form in …
Properties of membranes derived from the total lipids extracted from clear and cataractous lenses of 61–70-year-old human donors
Human lens-lipid membranes prepared from the total lipids extracted from clear and
cataractous lens cortexes and nuclei of 61–70-year-old donors by use of a rapid solvent …
cataractous lens cortexes and nuclei of 61–70-year-old donors by use of a rapid solvent …
Alpha-Crystallin Association with the Model of Human and Animal Eye Lens-Lipid Membranes Is Modulated by Surface Hydrophobicity of Membranes
R Timsina, G Trossi-Torres, J Thieme, M O'Dell… - Current eye …, 2022 - Taylor & Francis
Purpose This research aims to probe the interaction of α-crystallin with a model of human,
porcine, and mouse lens-lipid membranes. Methods Cholesterol/model of human lens-lipid …
porcine, and mouse lens-lipid membranes. Methods Cholesterol/model of human lens-lipid …