Antigen presentation lies at the heart of immune recognition of infected or malignant cells.
For this reason, important efforts have been made to predict which peptides are more likely …

Tumor exome and RNA sequencing data provide a systematic and unbiased view on cancer-
specific expression, over-expression, and mutations of genes, which can be mined for …

The HLA-DRB1 locus is strongly associated with rheumatoid arthritis (RA) susceptibility,
whereupon citrullinated self-peptides bind to HLA-DR molecules bearing the shared epitope …

Hyperglycemia and hyperlipidemia are often observed in individuals with type II diabetes
(T2D) and related mouse models. One dysmetabolic biochemical consequence is the non …

CD4+ helper T cells contribute important functions to the immune response during pathogen
infection and tumor formation by recognizing antigenic peptides presented by class II major …

Sequence homology between SARS-CoV-2 and common-cold human coronaviruses
(HCoVs) raises the possibility that memory responses to prior HCoV infection can affect T …

T cells play a critical role in the adaptive immune response, recognizing peptide antigens
presented on the cell surface by major histocompatibility complex (MHC) proteins. While …

Understanding peptide presentation by specific MHC alleles is fundamental for controlling
physiological functions of T cells and harnessing them for therapeutic use. However …

Seasonal “common-cold” human coronaviruses are widely spread throughout the world and
are mainly associated with mild upper respiratory tract infections. The emergence of highly …

The Major Histocompatibility Complex class I–related protein 1 (MR1) presents small
molecule metabolites, drugs, and drug-like molecules that are recognized by MR1-reactive T …