Introduction: Hepatocellular carcinoma (HCC) is a significant problem globally because of
viral infections and the increasing incidence of obesity and fatty liver disease. However, it is …

Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …

The protein phosphorylation status of exosomes can regulate the activity and function of
proteins related to cancer development, and it is highly possible to diagnose cancers …

Hepatocellular carcinoma (HCC) is among the most common malignancies and has an
unfavorable prognosis. The hepatitis B virus-encoded X (HBx) protein is closely associated …

Hepatoma is one of the most severe malignancies usually with poor prognosis, and many
patients are insensitive to the existing therapeutic agents, including the drugs for …

Background/Aims: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal
malignant tumors with poor prognosis. Conventional chemotherapies including gemcitabine …

A type of sorafenib‐(SOR‐) loaded long‐circulating nanoliposome was constructed, and the
targeting performance and antitumor effects of the prepared liposome were evaluated in the …

Background: Sorafenib (SOR) is an oral, potent, selective, irreversible epidermal growth
factor receptor tyrosine kinase inhibitor (EGFR-TKI) used as the first-line therapy for …

Introduction: This study reviews the evidence for the use of Bortezomib (BZB), a first-in-class
proteasome inhibitor in advanced Hepatocellular carcinoma (HCC). This review aims to …

The poor prognosis of hepatocellular carcinoma (HCC) is still an urgent challenge to be
solved worldwide. Hence, assembling drugs and targeted short peptides together to …