[HTML][HTML] Senescence and cancer—role and therapeutic opportunities

CA Schmitt, B Wang, M Demaria - Nature reviews Clinical oncology, 2022 - nature.com
Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …

Quercetin and its derivates as antiviral potentials: A comprehensive review

A Di Petrillo, G Orrù, A Fais… - Phytotherapy Research, 2022 - Wiley Online Library
Quercetin, widely distributed in fruits and vegetables, is a flavonoid known for its antioxidant,
antiviral, antimicrobial, and antiinflammatory properties. Several studies highlight the …

[HTML][HTML] Virus-induced senescence is a driver and therapeutic target in COVID-19

S Lee, Y Yu, J Trimpert, F Benthani, M Mairhofer… - Nature, 2021 - nature.com
Derailed cytokine and immune cell networks account for the organ damage and the clinical
severity of COVID-19 (refs.,,–). Here we show that SARS-CoV-2, like other viruses, evokes …

[HTML][HTML] COVID-19 and cellular senescence

CA Schmitt, T Tchkonia, LJ Niedernhofer… - Nature Reviews …, 2023 - nature.com
The clinical severity of coronavirus disease 2019 (COVID-19) is largely determined by host
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …

[HTML][HTML] Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?

TC Theoharides - Molecular Neurobiology, 2022 - Springer
SARS-CoV-2 infects cells via its spike protein binding to its surface receptor on target cells
and results in acute symptoms involving especially the lungs known as COVID-19. However …

Potential clinical benefits of quercetin in the early stage of COVID-19: results of a second, pilot, randomized, controlled and open-label clinical trial

F Di Pierro, S Iqtadar, A Khan… - … journal of general …, 2021 - Taylor & Francis
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the
cause of the ongoing global pandemic known as COVID-19. Based on the potential antiviral …

The therapeutic efficacy of quercetin in combination with antiviral drugs in hospitalized COVID-19 patients: A randomized controlled trial

M Shohan, R Nashibi, MR Mahmoudian-Sani… - European journal of …, 2022 - Elsevier
In this study, the therapeutic efficacy of quercetin in combination with remdesivir and
favipiravir, were evaluated in severe hospitalized COVID-19 patients. Our main objective …

[HTML][HTML] Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral …

K Evangelou, D Veroutis, K Paschalaki… - European …, 2022 - Eur Respiratory Soc
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of
the respiratory system can progress to a multisystemic disease with aberrant inflammatory …

[HTML][HTML] The therapeutic and prophylactic potential of quercetin against COVID-19: An outlook on the clinical studies, inventive compositions, and patent literature

M Imran, HK Thabet, SI Alaqel, AR Alzahrani, A Abida… - Antioxidants, 2022 - mdpi.com
Quercetin is a phenolic flavonol compound with established antioxidant, anti-inflammatory,
and immuno-stimulant properties. Recent studies demonstrate the potential of quercetin …

[HTML][HTML] Role of senescence and aging in SARS-CoV-2 infection and COVID-19 disease

SM Lynch, G Guo, DS Gibson, AJ Bjourson, TS Rai - Cells, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic associated with substantial …