Background Cancer is one of the most dangerous and widespread diseases in the world
today and it has risen to the position of the leading cause of death around the globe in the …

The development of new, effective drugs containing nitrogen and sulfur heteroatoms is of
paramount importance in medicinal chemistry. A versatile and rational approach for drug …

Cancer now is one of the leading causes of mortality in the world. There has been a lot of
effort to discover new anticarcinogenic agents that allow treatment with fewer side effects. A …

Isoxazole derivatives are one of the heterocyclic structures that have various biological
activities. Objective: This study aimed to design and synthesize novel isoxazole derivatives …

Abstract A series of 2-chloro-5-[(4-chlorophenyl) sulfamoyl]-N-(alkyl/aryl)-4-nitrobenzamide
derivatives (5a–5v) has been synthesized and confirmed by physicochemical (R f, melting …

A series of isoxazole derivatives (2a-i) were synthesized by conventional method using
various substituted chlorovinyl benzaldehydes as precursors. Structures of all the …

Sulfonamide and quinolone antibacterials are synthetic antimicrobial agents with broad
spectrum of activity. Discovery of these agents is a landmark in the history of development of …

Synthesis of some novel isoxazole derivatives and their molecular docking with enzymes
from CYP450 family carried out using erlotinib, gemcitabine and ketoconazole as reference …

Diabetes mellitus is a metabolic disorder characterized by an increase in blood glucose
beyond normal limits or hyperglycemia due to abnormalities in metabolic processes due to …

Novel isoxazole were designed and subjected for molecular docking study, which revealed
that the designed compounds possess significant to moderate interaction with the targeted …