Therapeutic potential of flavonoids in pain and inflammation: mechanisms of action, pre-clinical and clinical data, and pharmaceutical development

CR Ferraz, TT Carvalho, MF Manchope, NA Artero… - Molecules, 2020 - mdpi.com
Pathological pain can be initiated after inflammation and/or peripheral nerve injury. It is a
consequence of the pathological functioning of the nervous system rather than only a …

Citrus flavonoids and their antioxidant evaluation

Y Wang, XJ Liu, JB Chen, JP Cao, X Li… - Critical Reviews in …, 2022 - Taylor & Francis
The antioxidant ability is the link and bridge connecting a variety of biological activities.
Citrus flavonoids play an essential role in regulating oxidative stress and are an important …

Health-promoting effects of the citrus flavanone hesperidin

C Li, H Schluesener - Critical reviews in food science and nutrition, 2017 - Taylor & Francis
Hesperidin, a member of the flavanone group of flavonoids, can be isolated in large
amounts from the rinds of some citrus species. Considering the wide range of …

Nutraceuticals: facts and fiction

JC Espín, MT García-Conesa, FA Tomás-Barberán - Phytochemistry, 2007 - Elsevier
Epidemiological studies show a link between the consumption of plant-derived foods and a
range of health benefits. These benefits have been associated, at least partially, to some of …

Neuropharmacological properties and pharmacokinetics of the citrus flavonoids hesperidin and hesperetin—A mini-review

A Roohbakhsh, H Parhiz, F Soltani, R Rezaee… - Life sciences, 2014 - Elsevier
Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from citrus species
that have various biological properties. Over the past decade, a large number of papers …

Pharmacological significance of hesperidin and hesperetin, two citrus flavonoids, as promising antiviral compounds for prophylaxis against and combating COVID-19

PK Agrawal, C Agrawal… - Natural Product …, 2021 - journals.sagepub.com
Hesperidin and hesperetin are flavonoids that are abundantly present as constituents of
citrus fruits. These compounds have attracted attention as several computational methods …

Progress of research on the role of active ingredients of Citri Reticulatae Pericarpium in liver injury

S Gao, X Chen, Z Yu, R Du, B Chen, Y Wang, X Cai… - Phytomedicine, 2023 - Elsevier
Background Liver is a vital organ responsible for metabolizing and detoxifying both
endogenous and exogenous substances in the body. However, it is susceptible to damage …

Acute and sub-chronic oral toxicity studies of hesperidin isolated from orange peel extract in Sprague Dawley rats

Y Li, AD Kandhare, AA Mukherjee… - Regulatory Toxicology …, 2019 - Elsevier
Citrus sinensis contains glycoside hesperetin-7-rhamnoglucoside (hesperidin) which harbor
an array of therapeutic potentials including antioxidant, anticancer, and anti-inflammatory …

Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical marker to improve nerve functions

A Visnagri, AD Kandhare, S Chakravarty… - Pharmaceutical …, 2014 - Taylor & Francis
Aim: Diabetic neuropathy (DN) is one of the most common long-term complications of
diabetes mellitus and clinically can be characterized by an elevated nociceptive response …

[HTML][HTML] Hesperidin, a plant flavonoid accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats: Role of TGF-ß/Smads and Ang-1/Tie-2 …

W Li, AD Kandhare, AA Mukherjee, SL Bodhankar - EXCLI journal, 2018 - ncbi.nlm.nih.gov
Background: Delayed wound healing is a diverse, multifactorial, complex and inter-related
complication of diabetes resulting in significant clinical morbidity. Hesperidin possesses …