The many faces of Candida auris: Phenotypic and strain variation in an emerging pathogen

DJ Santana, G Zhao, TR O'Meara - Plos Pathogens, 2024 - journals.plos.org
Candida auris is an emerging fungal pathogen with unusual evolutionary history—there are
multiple distinct phylogeographic clades showing a near simultaneous transition from a …

The RNA content of fungal extracellular vesicles: At the “cutting-edge” of pathophysiology regulation

TA Bitencourt, AM Pessoni, BTM Oliveira, LR Alves… - Cells, 2022 - mdpi.com
The role of extracellular vesicles (EVs) in interkingdom communication is widely accepted,
and their role in intraspecies communication has been strengthened by recent research …

[HTML][HTML] Molecular characterization of Candida auris outbreak isolates in Qatar from patients with COVID-19 reveals the emergence of isolates resistant to three …

FB Abid, H Salah, S Sundararaju, L Dalil… - Clinical Microbiology …, 2023 - Elsevier
Objectives During the COVID-19 pandemic in Qatar, many patients who were severely ill
were colonized and infected by Candida auris, an invasive multidrug-resistant yeast …

Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection

J Bing, Z Guan, T Zheng, CL Ennis, CJ Nobile… - Nature …, 2024 - nature.com
Candida auris has become a serious threat to public health. The mechanisms of how this
fungal pathogen adapts to the mammalian host are poorly understood. Here we report the …

[HTML][HTML] Strain and temperature dependent aggregation of Candida auris is attenuated by inhibition of surface amyloid proteins

D Malavia-Jones, RA Farrer, MHT Stappers… - The Cell Surface, 2023 - Elsevier
Candida auris is a multi-drug resistant human fungal pathogen that has become a global
threat to human health due to its drug resistant phenotype, persistence in the hospital …

Candida auris undergoes adhesin-dependent and -independent cellular aggregation

C Pelletier, S Shaw, S Alsayegh, AJP Brown… - PLoS …, 2024 - journals.plos.org
Candida auris is a fungal pathogen of humans responsible for nosocomial infections with
high mortality rates. High levels of resistance to antifungal drugs and environmental …

Caspofungin Affects Extracellular Vesicle Production and Cargo in Candida auris

RF Amatuzzi, D Zamith-Miranda, IF Munhoz da Rocha… - Journal of Fungi, 2022 - mdpi.com
Antifungal resistance has become more frequent, either due to the emergence of naturally
resistant species or the development of mechanisms that lead to resistance in previously …

Development of Echinocandin Resistance in Candida haemulonii: An Emergent, Widespread, and Opportunistic Fungal Pathogen

LN Silva, LS Ramos, SSC Oliveira, LB Magalhães… - Journal of Fungi, 2023 - mdpi.com
Echinocandins, used for the prevention and treatment of invasive fungal infections, have led
to a rise in breakthrough infections caused by resistant Candida species. Among these …

Evolutionary accumulation of FKS1 mutations from clinical echinocandin-resistant Candida auris

S Tian, Y Wu, H Li, C Rong, N Wu, Y Chu… - Emerging Microbes & …, 2024 - Taylor & Francis
Introduction: Drug resistance to echinocandins, first-line drugs used to treat Candida auris
infection, is rapidly emerging. However, the accumulation of mutations in genes other than …

Cellular and Extracellular Vesicle RNA Analysis in the Global Threat Fungus Candida auris

IF Munhoz da Rocha, ST Martins… - Microbiology …, 2021 - Am Soc Microbiol
Emerging and reemerging pathogens are a worldwide concern, and it is predicted that these
microbes will cause severe outbreaks. Candida auris affects people with weakened immune …