T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

In addition to CD4+ T cells and neutralizing antibodies, CD8+ T cells contribute to protective
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …

In the context of relapsed and refractory childhood pre-B cell acute lymphoblastic leukemia
(R/R B-ALL), CD19-targeting chimeric antigen receptor (CAR)-T cells often induce durable …

Autologous chimeric antigen receptor (CAR) T cell therapies targeting CD19 have high
efficacy in large B cell lymphomas (LBCLs), but long-term remissions are observed in less …

The transcription factors nuclear factor of activated T cells (NFAT) and activator protein 1 (AP-
1; Fos–Jun) cooperate to promote the effector functions of T cells, but NFAT in the absence …

The efficacy of adoptive T-cell therapies largely depends on the generation of T-cell
populations that provide rapid effector function and long-term protective immunity. Yet it is …

Understanding complex tissues requires single-cell deconstruction of gene regulation with
precision and scale. Here, we assess the performance of a massively parallel droplet-based …

A common theme across multiple successful immunotherapies for cancer is the recognition
of tumor-specific mutations (neoantigens) by T cells. The rapid discovery of such antigen …

Cell therapies present an entirely new paradigm in drug development. Within this class,
immune cell therapies are among the most advanced, having already demonstrated …

Chimeric antigen receptor (CAR) T cells mediate anti-tumour effects in a small subset of
patients with cancer,–, but dysfunction due to T cell exhaustion is an important barrier to …