Many ATP-and GTP-binding proteins have a phosphate-binding loop (P-loop), the primary
structure of which typically consists of a glycine-rich sequence followed by a conserved …

(Controversy is an integral part of scientific research and is often a precursor to the truth.
However, this lesson has been learned in a very hard way in the case of the structure …

The structure of adenylate kinase from Escherichia coli ligated with the two-
substratemimicking inhibitor P 1, P 5-bis (adenosine-5′-) pentaphosphate has been …

In type 2 diabetes, the liver produces excessive amounts of glucose through the
gluconeogenesis (GNG) pathway and consequently is partly responsible for the elevated …

The gene encoding for an extremely thermostable oligo-1, 6-glucosidase from Bacillus
thermoglucosidasius KP1006 (DSM2542, obligate thermophile) was sequenced. The amino …

AMP binding sites are commonly used by nature for allosteric regulation of enzymes
controlling the production and metabolism of carbohydrates and lipids. Since many of these …

Glycogen synthases from Escherichia coli and mammalian muscle differ in many respects
including regulation, sugar nucleotide specificity, and primary sequence. To compare the …

Inhibition of FBPase is considered a promising way to reduce hepatic gluconeogenesis and
therefore could be a potential approach to treat type 2 diabetes. Herein we report the …

Twelve herpesviral deoxythymidine kinases were examined for regions of sequence
similarity by multiple alignment. Six highly conserved sites were observed. Site 1 …

Here, researchers review the latest breakthroughs in protein research. Their contributions
explore emerging principles and techniques and survey important classes of proteins that …