Epigenetics involves a series of mechanisms that entail histone and DNA covalent
modifications and non-coding RNAs, and that collectively contribute to programing cell …

Alcohol use disorder (AUD) is a very common and complex disease, as alcohol is the most
widely used addictive drug in the world. This disorder has an enormous impact on public …

The rye genome has a large size with a high level of cytosine methylation, which makes it
particularly convenient for studying the occurrence of potential cytosine demethylation …

Four DNA bases are essential biochemical elements for coding heritable life blueprint.
Meanwhile, organisms utilize modifying enzymes to post chemical groups on DNA bases to …

Recently described as the sixth base of the DNA macromolecule, the precise role of 5-
hydroxymethylcytosine (5hmC) is the subject of debate. Early studies indicate that it is …

Abstract Background Systemic sclerosis (SSc) is a rare autoimmune disease characterized
by progressive fibrosis of the skin and internal organs. Besides genetics risk factors …

Methylcytosine (5mC) is an epigenetic modification involved in regulation of gene
expression in metazoans and plants. Iron-(II)/α-ketoglutarate-dependent dioxygenases can …

Background DNA adducts, covalent modifications to DNA due to exposure to specific
carcinogens, cause the mispairing of DNA bases, which ultimately results in DNA mutations …

Epigenetic modifications are closely related to certain disorders of the organism, including
the development of tumors. One of the main epigenetic modifications is the methylation of …

Ultraviolet A (UVA) radiation is harmful for living organisms but in low doses may stimulate
cell proliferation. Our aim was to examine the relationships between exposure to different …