Radioactive main group and rare earth metals for imaging and therapy

TI Kostelnik, C Orvig - Chemical reviews, 2018 - ACS Publications
Radiometals possess an exceptional breadth of decay properties and have been applied to
medicine with great success for several decades. The majority of current clinical use …

Matching chelators to radiometals for radiopharmaceuticals

EW Price, C Orvig - Chemical Society Reviews, 2014 - pubs.rsc.org
Radiometals comprise many useful radioactive isotopes of various metallic elements. When
properly harnessed, these have valuable emission properties that can be used for …

Coordinating radiometals of copper, gallium, indium, yttrium, and zirconium for PET and SPECT imaging of disease

TJ Wadas, EH Wong, GR Weisman… - Chemical …, 2010 - ACS Publications
Molecular imaging is the visualization, characterization, and measurement of biological
processes at the molecular and cellular levels in humans and other living systems …

Molecular imaging of cancer with positron emission tomography

SS Gambhir - Nature Reviews Cancer, 2002 - nature.com
The imaging of specific molecular targets that are associated with cancer should allow
earlier diagnosis and better management of oncology patients. Positron emission …

Radiometals for combined imaging and therapy

CS Cutler, HM Hennkens, N Sisay… - Chemical …, 2013 - ACS Publications
The use of radionuclides in medicine is based largely on the discoveries of two critical
concepts, the “tracer principle” and the “magic bullet”. In 1913, George de Hevesy …

The diagnosis and medical management of advanced neuroendocrine tumors

GA Kaltsas, GM Besser, AB Grossman - Endocrine reviews, 2004 - academic.oup.com
Neuroendocrine tumors (NETs) constitute a heterogeneous group of neoplasms that
originate from endocrine glands such as the pituitary, the parathyroids, and the …

Copper-64 radiopharmaceuticals for PET imaging of cancer: advances in preclinical and clinical research

CJ Anderson, R Ferdani - Cancer Biotherapy and …, 2009 - liebertpub.com
Summation Copper-64 (T1/2= 12.7 hours; β+, 0.653 MeV [17.8%]; β−, 0.579 MeV [38.4%])
has decay characteristics that allow for positron emission tomography (PET) imaging and …

Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis

M Nahrendorf, H Zhang, S Hembrador, P Panizzi… - Circulation, 2008 - Am Heart Assoc
Background—Macrophages participate centrally in atherosclerosis, and macrophage
markers (eg, CD68, MAC-3) correlate well with lesion severity and therapeutic modulation …

A Perspective–can copper complexes be developed as a novel class of therapeutics?

M Wehbe, AWY Leung, MJ Abrams, C Orvig… - Dalton …, 2017 - pubs.rsc.org
Although copper–ligand complexes appear to be promising as a new class of therapeutics,
other than the family of copper (II) coordination compounds referred to as casiopeínas these …

[HTML][HTML] Somatostatin receptor PET ligands-the next generation for clinical practice

E Pauwels, F Cleeren, G Bormans… - American Journal of …, 2018 - ncbi.nlm.nih.gov
Somatostatin receptors (SSTRs) are variably expressed by a variety of malignancies. Using
radiolabeled somatostatin analogs (SSAs), the presence of SSTRs on tumor cells may be …