Polymorphism and solvatomorphism 2010

HG Brittain - Journal of pharmaceutical sciences, 2012 - Elsevier
Papers and patents that deal with polymorphism (crystal systems for which a substance can
exist in structures defined by different unit cells and where each of the forms has the same …

Carvedilol

K Beattie, G Phadke, J Novakovic - Profiles of drug substances, excipients …, 2013 - Elsevier
Abstract Carvedilol ((2RS)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy) ethyl] amino]
propan-2-ol), a β1-, β2-, and α1-adrenoreceptor blocker drug with antioxidant and …

Carvedilol: solubilization and cyclodextrin complexation: a technical note

T Loftsson, SB Vogensen, C Desbos, P Jansook - AAPs PharmSciTech, 2008 - Springer
Carvedilol (Table I) is a non-selective β-blocker indicated in the treatment of mild to
moderate congestive heart failure. It also has vasodilating properties that are mainly …

Determination of the optimal molar ratio in amino acid-based coamorphous systems

J Liu, T Rades, H Grohganz - Molecular Pharmaceutics, 2020 - ACS Publications
Coamorphous drug formulations are a promising approach to improve solubility and
bioavailability of poorly water-soluble drugs. On the basis of theoretical assumptions …

Solving the computational puzzle: Toward a pragmatic pathway for modeling low-energy vibrational modes of pharmaceutical crystals

K Be̅rziņš, JJ Sutton, SJ Fraser-Miller… - Crystal Growth & …, 2020 - ACS Publications
Five pharmaceutically relevant compounds with increasing molecular complexity, benzoic
acid, diphenylacetic acid, l-tyrosine, celecoxib (form III), and carvedilol (form II), were …

Pharmaceutical Salts of Carvedilol with Increased Solubility as an Approach for Enhancing the Drug Action

JA Pereira, LF Diniz, C W. Lehmann… - Crystal Growth & …, 2024 - ACS Publications
Carvedilol (CVD) is a β-blocker antihypertensive drug commonly used to treat
cardiovascular disorders. Since the poor oral bioavailability of CVD can be improved directly …

An insight into carvedilol solid forms: effect of supramolecular interactions on the dissolution profiles

LD Prado, HVA Rocha, JALC Resende, GB Ferreira… - …, 2014 - pubs.rsc.org
Carvedilol, a β-blocker drug used to treat hypertension, is known to exhibit polymorphism.
Thus far, the crystal structure of two polymorphs (I and II) and one hydrate have been …

Formation of pharmaceutical salts and cocrystals via vapour-assisted tumbling (VAT)–a solvent efficient process

AJ Stirk, FES Souza, J Gerster, FM Mir… - Green …, 2022 - pubs.rsc.org
Crystallisations on both the academic and industrial scale often use large volumes of
solvent. In order to decrease the environmental impact of such processes, new techniques …

[HTML][HTML] Application of advanced thermal analysis for characterization of crystalline and amorphous phases of carvedilol

M Skotnicki, A Czerniecka-Kubicka, G Neilsen… - … of Pharmaceutical and …, 2022 - Elsevier
The thermal behaviour of crystalline and amorphous carvedilol (CAR) phases was studied
by advanced thermal analysis using Quantum Design Physical Property Measurement …

Thermal behavior and molecular mobility studies in the supercooled liquid and glassy states of carvedilol and loratadine

MT Viciosa, JJM Ramos, HP Diogo - International Journal of Pharmaceutics, 2020 - Elsevier
The thermal behavior of carvedilol and loratadine was studied by differential scanning
calorimetry (DSC). The glass-forming ability, as well as the the tendency for crystallization …