Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses among all
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …
Cyclin dependent kinase (CDK) inhibitors as anticancer drugs: Recent advances (2015–2019)
C Sánchez-Martínez, MJ Lallena… - Bioorganic & medicinal …, 2019 - Elsevier
Sustained proliferative capacity and gene dysregulation are hallmarks of cancer. In
mammalian cells, cyclin-dependent kinases (CDKs) control critical cell cycle checkpoints …
mammalian cells, cyclin-dependent kinases (CDKs) control critical cell cycle checkpoints …
Phytochemicals as potential anticancer drugs: time to ponder nature's bounty
MA Ashraf - BioMed research international, 2020 - Wiley Online Library
Medicinal plants have been used from the beginning of human civilization, which is mostly
evident from the ancient script and traditional herbal medicine recipe. Despite the historically …
evident from the ancient script and traditional herbal medicine recipe. Despite the historically …
Saponins in cancer treatment: Current progress and future prospects
Saponins are steroidal or triterpenoid glycoside that is distinguished by the soap-forming
nature. Different saponins have been characterized and purified and are gaining attention in …
nature. Different saponins have been characterized and purified and are gaining attention in …
Anticancer effects with molecular docking confirmation of newly synthesized isatin sulfonamide molecular hybrid derivatives against hepatic cancer cell lines
The current study investigated the cytotoxic effect of ten sulfonamide-derived isatins,
following molecular hybridization, based on the association principles, on hepatocellular …
following molecular hybridization, based on the association principles, on hepatocellular …
The efficacy of natural bioactive compounds against prostate cancer: Molecular targets and synergistic activities
Globally, prostate cancer (PCa) is regarded as a challenging health issue, and the number
of PCa patients continues to rise despite the availability of effective treatments in recent …
of PCa patients continues to rise despite the availability of effective treatments in recent …
[HTML][HTML] Repositioning of fluoroquinolones from antibiotic to anti-cancer agents: An underestimated truth
Increasing development costs and higher failure rate in clinical trials has reduced the
repertoire of newer drugs in the market for clinical use. The most appropriate approach to …
repertoire of newer drugs in the market for clinical use. The most appropriate approach to …
The involvement of ubiquitination machinery in cell cycle regulation and cancer progression
T Zou, Z Lin - International Journal of Molecular Sciences, 2021 - mdpi.com
The cell cycle is a collection of events by which cellular components such as genetic
materials and cytoplasmic components are accurately divided into two daughter cells. The …
materials and cytoplasmic components are accurately divided into two daughter cells. The …
Lessons learned from past cyclin-dependent kinase drug discovery efforts
Z Xie, S Hou, X Yang, Y Duan, J Han… - Journal of Medicinal …, 2022 - ACS Publications
Inhibition of cyclin-dependent kinases (CDKs) has become an effective therapeutic strategy
for treating various diseases, especially cancer. Over almost three decades, although great …
for treating various diseases, especially cancer. Over almost three decades, although great …
E3 ubiquitin ligase TRIM proteins, cell cycle and mitosis
S Venuto, G Merla - Cells, 2019 - mdpi.com
The cell cycle is a series of events by which cellular components are accurately segregated
into daughter cells, principally controlled by the oscillating activities of cyclin-dependent …
into daughter cells, principally controlled by the oscillating activities of cyclin-dependent …