Functionalized sulfur-containing heterocyclic analogs induce sub-G1 arrest and apoptotic cell death of laryngeal carcinoma in vitro
B Haridevamuthu, T Manjunathan… - Molecules, 2023 - mdpi.com
In this study, we speculate that the hydroxyl-containing benzo [b] thiophene analogs, 1-(3-
hydroxybenzo [b] thiophen-2-yl) ethanone (BP) and 1-(3-hydroxybenzo [b] thiophen-2-yl) …
hydroxybenzo [b] thiophen-2-yl) ethanone (BP) and 1-(3-hydroxybenzo [b] thiophen-2-yl) …
Dual-emission dye@ MIL-101 (Al) composite as fluorescence sensor for the selective and sensitive detection towards arginine
N Song, Z Zhai, L Yang, D Zhang, Z Zhou - Journal of Solid State Chemistry, 2023 - Elsevier
The application of fluorescence molecules in imaging, sensors, and other fields has
attracted extensive attention. However, the inherent problems of aggregation-caused …
attracted extensive attention. However, the inherent problems of aggregation-caused …
Rottlerin renders a selective and highly potent CYP2C8 inhibition to impede EET formation for implication in cancer therapy
CYP2C8 is a crucial CYP isoform responsible for the metabolism of xenobiotics and
endogenous molecules. CYP2C8 converts arachidonic acid to epoxyeicosatrienoic acids …
endogenous molecules. CYP2C8 converts arachidonic acid to epoxyeicosatrienoic acids …
Glabridin plays dual action to intensify anti-metastatic potential of paclitaxel via impeding CYP2C8 in liver and CYP2J2/EETs in tumor of an orthotopic mouse model of …
A Jamwal, J Chand, A Dash, S Bhatt, S Dhiman… - Chemico-Biological …, 2023 - Elsevier
In spite of unprecedented advances in modern cancer therapy, there is still a dearth of
targeted therapy to circumvent triple-negative breast cancer (TNBC). Paclitaxel is the front …
targeted therapy to circumvent triple-negative breast cancer (TNBC). Paclitaxel is the front …
Multitargeted C9‐substituted ester and ether derivatives of berberrubine for Alzheimer's disease: Design, synthesis, biological evaluation, metabolic stability, and …
R Raghuvanshi, A Jamwal, U Nandi… - Drug Development …, 2023 - Wiley Online Library
Berberrubine is a naturally occurring isoquinoline alkaloid and a bioactive metabolite of
berberine. Berberine exhibits a wide range of pharmacological activities, including …
berberine. Berberine exhibits a wide range of pharmacological activities, including …
[HTML][HTML] Physiological modeling of the metaverse of the Mycobacterium tuberculosis β-CA inhibition mechanism
Tuberculosis (TB) is an infectious disease that primarily affects the lungs of humans and
accounts for Mycobacterium tuberculosis (Mtb) bacteria as the etiologic agent. In this study …
accounts for Mycobacterium tuberculosis (Mtb) bacteria as the etiologic agent. In this study …
EIDD-1931 Treatment Tweaks CYP3A4 and CYP2C8 in Arthritic Rats to Expedite Drug Interaction: Implication in Oral Therapy of Molnupiravir
EIDD-1931 is the active form of molnupiravir, an orally effective drug approved by the United
States Food and Drug Administration (USFDA) against COVID-19. Pharmacokinetic …
States Food and Drug Administration (USFDA) against COVID-19. Pharmacokinetic …
ADME/PK Insights of Crocetin: A Molecule Having an Unusual Chemical Structure with Druglike Features
Crocetin is a promising phyto-based molecule to treat Alzheimer's disease (AD). The
chemical structure of crocetin is incongruent with various standard structural features of CNS …
chemical structure of crocetin is incongruent with various standard structural features of CNS …
Sustained release polymer and surfactant based solid dispersion of andrographolide exhibited improved solubility, dissolution, pharmacokinetics, and …
Andrographolide (AD) is a potent natural product with a wide range of pharmacological
activities. However, it has low oral bioavailability due to poor solubility and dissolution rate …
activities. However, it has low oral bioavailability due to poor solubility and dissolution rate …
[PDF][PDF] Exploring the potential of natural feed additives from herbs as an alternative to antibiotic growth promoters for Mojosari layer duck (Anas javanica) farming: in …
IH Djunaidi, CA Damayanti… - Journal of the …, 2023 - pdfs.semanticscholar.org
Using synthetic feed additive, such as antibiotic growth promoters (AGPs), is common in
Mojosari layer duck (Anas javanica) farms. Their purpose is to enhance growth and …
Mojosari layer duck (Anas javanica) farms. Their purpose is to enhance growth and …