NKG2D is an activating receptor expressed by all NK cells and subsets of T cells. It serves
as a major recognition receptor for detection and elimination of transformed and infected …

The activating receptor NKG2D is peculiar in its capability to bind to numerous and highly
diversified MHC class I-like self-molecules. These ligands are poorly expressed on normal …

Natural killer (NK) cells are innate lymphoid cells, and their presence within human tumors
correlates with better prognosis. However, the mechanisms by which NK cells control tumors …

Immune checkpoint inhibitors (ICI) revolutionized the field of immuno-oncology and opened
new avenues towards the development of novel assets to achieve durable immune control …

DNA damage, oncogene activation and excessive proliferation, chromatin modulations or
oxidative stress are all important hallmarks of cancer. Interestingly, all of these abnormalities …

Natural killer (NK) cells are central components of the innate immunity. In murine models, it
has been shown that NK cells can control both local tumor growth and metastasis due to …

The main cause of death in melanoma patients is widespread metastases. Staging of
melanoma is based on the primary tumor thickness, ulceration, lymph node and distant …

Tumors contain variable numbers of lymphocytes, referred to as tumor infiltrating
lymphocytes (TILs). In melanoma, the intensity of this lymphocytic infiltrate is believed to …

Initially described as effectors of natural cytotoxicity and critical players for the control of viral
infections and tumor growth, recent investigations unraveled more widespread functions for …

Background: Major histocompatibility complex (MHC) class I chain-related protein A (MICA)
and MHC class I chain-related protein B (MICB) are polymorphic proteins that are induced …