The complement system is an evolutionarily ancient key component of innate immunity
required for the detection and removal of invading pathogens. It was discovered more than …

The complement system, an arm of the innate immune system plays a critical role in both
health and disease. The complement system is highly complex with dual possibilities …

In this study we demonstrate a new form of immunoregulation: engagement on CD4+ T cells
of the complement regulator CD46 promoted the effector potential of T helper type 1 cells …

Decay-accelerating factor (Daf) dissociates C3/C5 convertases that assemble on host cells
and thereby prevents complement activation on their surfaces. We demonstrate that during …

Myocarditis is a principal cause of heart disease among young adults and is often a
precursor of heart failure due to dilated cardiomyopathy. We show here that complement is …

In addition to its established role in innate immune mechanisms, complement component C3
is also of critical importance in B cell activation and T cell-dependent Ab responses. In this …

A key component of both innate and adaptive immunity, new understandings of the
complement system are expanding its roles beyond that traditionally appreciated. Evidence …

Complement is not only part of the innate immune system, but has also been implicated in
adaptive immunity. The role of complement and its regulatory proteins in modulating T cell …

A newly recognized link between the complement system and adaptive immunity is that
decay accelerating factor (DAF), a cell surface C3/C5 convertase regulator, exerts control …

Studies over the past three decades have clearly established a central role for complement
in the promotion of a humoral immune response. The primary function of complement, in this …