To create a drug, nature's blueprints often have to be improved through semisynthesis or
total synthesis (chemical postevolution). Selected contributions from industrial and academic …

The glycopeptide antimicrobials are a group of natural product and semisynthetic
glycosylated peptides that show antibacterial activity against Gram-positive organisms …

The war against infectious bacteria is not over! Although vancomycin and glycopeptide
antibiotics have provided a strong last line of defence against many drug‐resistant bacteria …

A last line of defence against “superbugs” are the vancomycin group antibiotics. This review
describes the determination of their mode of action, and a mechanism of resistance to them …

Recent advances in ab initio direct methods have enabled the solution of crystal structures
of small proteins from native X-ray data alone, that is, without the use of fragments of known …

SnB is a direct-methods program based on the Shake-and-Bake methodology. It has been
used to solve difficult or large structures that could not be solved by traditional reciprocal …

This book provides basic principles of multivalent interactions found in biological systems as
well as an up-to-date and thorough coverage in design concepts, syntheses, and biological …

Natural anion binding systems achieve high substrate affinity and selectivity most often by
arranging converging binding sites inside a cavity or cleft that is well shielded from …

Abstract Zur Entwicklung von Medikamenten müssen die Strukturvorlagen aus der Natur oft
durch Semisynthese oder Totalsynthese verbessert werden (chemische Post‐Evolution) …

Abstract Der Krieg gegen pathogene Bakterien ist noch nicht vorbei! Zwar bilden
Vancomycin und andere Glycopeptid‐Antibiotika eine letzte Verteidigungslinie gegen …