Obesity-induced neuroinflammation: beyond the hypothalamus
O Guillemot-Legris, GG Muccioli - Trends in neurosciences, 2017 - cell.com
Obesity is now a worldwide health issue. Far from being limited to weight gain, obesity is
generally associated with low-grade inflammation and with a cluster of disorders collectively …
generally associated with low-grade inflammation and with a cluster of disorders collectively …
The cellular and molecular bases of leptin and ghrelin resistance in obesity
Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases
and certain types of cancer, arises from a chronic positive energy balance that is often due to …
and certain types of cancer, arises from a chronic positive energy balance that is often due to …
The vagus nerve in appetite regulation, mood, and intestinal inflammation
KN Browning, S Verheijden, GE Boeckxstaens - Gastroenterology, 2017 - Elsevier
Although the gastrointestinal tract contains intrinsic neural plexuses that allow a significant
degree of independent control over gastrointestinal functions, the central nervous system …
degree of independent control over gastrointestinal functions, the central nervous system …
LEAP2 changes with body mass and food intake in humans and mice
Acyl-ghrelin administration increases food intake, body weight, and blood glucose. In
contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit life-threatening …
contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit life-threatening …
Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism
M Soto, C Herzog, JA Pacheco, S Fujisaka… - Molecular …, 2018 - nature.com
Obesity and diabetes in humans are associated with increased rates of anxiety and
depression. To understand the role of the gut microbiome and brain insulin resistance in …
depression. To understand the role of the gut microbiome and brain insulin resistance in …
Therapeutic potential of targeting the ghrelin pathway
Ghrelin was discovered in 1999 as the endogenous ligand of the growth-hormone
secretagogue receptor 1a (GHSR1a). Since then, ghrelin has been found to exert a plethora …
secretagogue receptor 1a (GHSR1a). Since then, ghrelin has been found to exert a plethora …
[HTML][HTML] One-day high-fat diet induces inflammation in the nodose ganglion and hypothalamus of mice
A high-fat diet (HFD) induces inflammation in systemic organs including the hypothalamus,
resulting in obesity and diabetes. The vagus nerve connects the visceral organs and central …
resulting in obesity and diabetes. The vagus nerve connects the visceral organs and central …
Obesity impairs the action of the neuroendocrine ghrelin system
Ghrelin is a metabolic hormone that promotes energy conservation by regulating appetite
and energy expenditure. Although some studies suggest that antagonizing ghrelin function …
and energy expenditure. Although some studies suggest that antagonizing ghrelin function …
[HTML][HTML] LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue
Objective The hormone liver-expressed antimicrobial peptide-2 (LEAP2) is a recently
identified antagonist and an inverse agonist of the growth hormone secretagogue receptor …
identified antagonist and an inverse agonist of the growth hormone secretagogue receptor …
The critical role of CCK in the regulation of food intake and diet-induced obesity
CR Cawthon, CB de La Serre - Peptides, 2021 - Elsevier
Abstract In 1973, Gibbs, Young, and Smith showed that exogenous cholecystokinin (CCK)
administration reduces food intake in rats. This initial report has led to thousands of studies …
administration reduces food intake in rats. This initial report has led to thousands of studies …